SKIL

Last updated
SKIL
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SKIL , SNO, SnoA, SnoI, SnoN, SKI-like proto-oncogene, SKI like proto-oncogene
External IDs OMIM: 165340 MGI: 106203 HomoloGene: 3948 GeneCards: SKIL
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145097
NM_001145098
NM_001248008
NM_005414

RefSeq (protein)

NP_001138569
NP_001138570
NP_001234937
NP_005405

Location (UCSC) Chr 3: 170.36 – 170.4 Mb Chr 3: 31.15 – 31.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ski-like protein is a protein that in humans is encoded by the SKIL gene. [5] [6]

Contents

Interactions

SKIL interacts with SKI protein, [7] Mothers against decapentaplegic homolog 3 [8] [9] and Mothers against decapentaplegic homolog 2. [8] [9]

Protein Family

SKIL belongs to the Ski/Sno/Dac family, shared by SKI protein, Dachshund, and SKIDA1. [10] Members of the Ski/Sno/Dac family share a domain that is roughly 100 amino acids long.

Related Research Articles

<span class="mw-page-title-main">Mothers against decapentaplegic homolog 2</span> Protein-coding gene in the species Homo sapiens

Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

<span class="mw-page-title-main">Mothers against decapentaplegic homolog 3</span> Protein-coding gene in humans

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

<span class="mw-page-title-main">Mothers against decapentaplegic homolog 6</span> Protein-coding gene in the species Homo sapiens

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.

<span class="mw-page-title-main">SKI protein</span> Protein-coding gene in the species Homo sapiens

The SKI protein is a nuclear proto-oncogene that is associated with tumors at high cellular concentrations. SKI has been shown to interfere with normal cellular functioning by both directly impeding expression of certain genes inside the nucleus of the cell as well as disrupting signaling proteins that activate genes.

<span class="mw-page-title-main">Small nucleolar RNA SNORD15</span>

In molecular biology, SNORD15 is a non-coding RNA (ncRNA) molecule which functions in the modification of small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD36</span>

In molecular biology, snoRNA U36 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Myocyte-specific enhancer factor 2A</span> Protein-coding gene in the species Homo sapiens

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.

<span class="mw-page-title-main">SNW1</span> Protein-coding gene in the species Homo sapiens

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.

<span class="mw-page-title-main">Ubiquitin A-52 residue ribosomal protein fusion product 1</span> Human protein

60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.

<span class="mw-page-title-main">60S ribosomal protein L7a</span> Protein-coding gene in the species Homo sapiens

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.

<span class="mw-page-title-main">DLX3</span> Mammalian protein found in Homo sapiens

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

<span class="mw-page-title-main">HMGN2</span> Protein-coding gene in the species Homo sapiens

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene.

<span class="mw-page-title-main">40S ribosomal protein S13</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.

<span class="mw-page-title-main">SMURF2</span>

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.

<span class="mw-page-title-main">KLF10</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

<span class="mw-page-title-main">PRRX1</span> Protein-coding gene in the species Homo sapiens

Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.

<span class="mw-page-title-main">NFIX</span> Protein-coding gene in the species Homo sapiens

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.

<span class="mw-page-title-main">VPS39</span> Protein-coding gene in the species Homo sapiens

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.

<span class="mw-page-title-main">ZNF143</span> Protein-coding gene

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

<span class="mw-page-title-main">GFI1B</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136603 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027660 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nomura N; Sasamoto S; Ishii S; Date T; Matsui M; Ishizaki R (September 1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno". Nucleic Acids Res. 17 (14): 5489–500. doi:10.1093/nar/17.14.5489. PMC   318172 . PMID   2762147.
  6. "Entrez Gene: SKIL SKI-like oncogene".
  7. Cohen, S B; Zheng G; Heyman H C; Stavnezer E (February 1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. ENGLAND. 27 (4): 1006–14. doi:10.1093/nar/27.4.1006. ISSN   0305-1048. PMC   148280 . PMID   9927733.
  8. 1 2 Stroschein, S L; Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. United States. 15 (21): 2822–36. doi:10.1101/gad.912901. ISSN   0890-9369. PMC   312804 . PMID   11691834.
  9. 1 2 Stroschein, S L; Wang W; Zhou S; Zhou Q; Luo K (October 1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein". Science . UNITED STATES. 286 (5440): 771–4. doi:10.1126/science.286.5440.771. ISSN   0036-8075. PMID   10531062.
  10. "Conserved Protein Domain Family Ski_Sno". NCBI. Retrieved 5 May 2019.

Further reading