SLU-PP-332

Last updated

SLU-PP-332
SLU-PP-332.svg
Names
Preferred IUPAC name
4-Hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide
Other names
SLU-PP-332
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
  • InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12-
    Key: RNZIMBFHRXYRLL-UNOMPAQXSA-N
  • C1=CC=C2C=C(C=CC2=C1)/C=N\NC(=O)C3=CC=C(C=C3)O
Properties
C18H14N2O2
Molar mass 290.322 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

SLU-PP-332 is a compound which is a potent but non-selective estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity. [1] [2] [3] [4] [5]

References

  1. ↑ US 8680150,Zhi L, Hudson AR, Van Oeveren CA, Roach SL, Pickens JC, Shen Y, Cuervo C, Valdez LJ, Basinger J, Grant VH,"Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors.",issued 25 March 2014, assigned to Ligand Pharmaceuticals Inc.
  2. ↑ Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, et al. (April 2023). "Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity". ACS Chemical Biology. 18 (4): 756–771. doi:10.1021/acschembio.2c00720. PMC   11584170 . PMID   36988910. S2CID   257803892.
  3. ↑ Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, et al. (September 2023). "A Synthetic ERR Agonist Alleviates Metabolic Syndrome". The Journal of Pharmacology and Experimental Therapeutics. 388 (2): 232–240. doi: 10.1124/jpet.123.001733 . PMC   10801787 . PMID   37739806. S2CID   262147173.
  4. ↑ Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, et al. (September 2023). "Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney". The American Journal of Pathology. 193 (12): 1969–1987. doi:10.1016/j.ajpath.2023.07.008. PMC   10734281 . PMID   37717940. S2CID   262046570.
  5. ↑ "Exercise-mimicking drug sheds weight, boosts muscle activity in mice". news.ufl.edu. Retrieved 2023-10-05.
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