SSMEM1

Last updated
SSMEM1
Identifiers
Aliases SSMEM1 , C7orf45, serine-rich single-pass membrane protein 1, serine rich single-pass membrane protein 1
External IDs MGI: 1922897 HomoloGene: 12615 GeneCards: SSMEM1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145268

NM_027073
NM_029373

RefSeq (protein)

NP_660311

n/a

Location (UCSC) Chr 7: 130.21 – 130.22 Mb Chr 6: 30.51 – 30.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene. [5]

Contents

Gene

The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45. [6] [7] Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans. [8] The human mRNA transcript is 1171 bp long with three exons. [9]

Aliases

In humans, SSMEM1 is also referred to as C7orf45. [8] Human SSMEM1 has a clone name of FLJ40316. [8]

Expression

In humans, SSMEM1 is highly expressed in the testes. [10] [ failed verification ] [11] [12] In mice, SSMEM1 is expressed in the brain. [13]

Protein

In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55. [5] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243). [5] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long. [5] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64. [5] [14]

Related Research Articles

<span class="mw-page-title-main">TMEM242</span> Protein-coding gene in the species Homo sapiens

Transmembrane protein 242 (TMEM242) is a protein that in humans is encoded by the TMEM242 gene. The tmem242 gene is located on chromosome 6, on the long arm, in band 2 section 5.3. This protein is also commonly called C6orf35, BM033, and UPF0463 Transmembrane Protein C6orf35. The tmem242 gene is 35,238 base pairs long, and the protein is 141 amino acids in length. The tmem242 gene contains 4 exons. The function of this protein is not well understood by the scientific community. This protein contains a DUF1358 domain.

<span class="mw-page-title-main">C9orf64</span> Protein-coding gene in the species Homo sapiens

C9orf64 is a gene located on chromosome 9, that in humans encodes the protein queuosine salvage protein. The function and biological process of the queuosine salvage protein is a queuosine-nucleotide N-glycosylase/hydrolase (QNG1) that releases queuine from Q-5'-monophosphate, and this activity is required for the salvage of queuine from exogenous Queuosine by S. pombe and HeLa cells. Some evidence from orthologs indicates it may be involved in tRNA processing and recycling. The most common mRNA contains 4 coding exons, and it has 2 additional alternatively spliced exons. C9orf64 has been found in 5 different splice variants.

<span class="mw-page-title-main">FAM203B</span> Protein-coding gene in the species Homo sapiens

Family with Sequence Similarity 203, Member B (FAM203B) is a protein encoded by the FAM203B gene (8q24.3) in humans. While FAM203B is only found in humans and possibly non-human primates, its paralog, FAM203A, is highly conserved. The FAM203B protein contains two conserved domains of unknown function, DUF383 and DUF384, and no transmembrane domains. This protein has no known function yet, although the homolog of FAM203A in Caenorhabditis elegans (Y54H5A.2) is thought to help regulate the actin cytoskeleton.

<span class="mw-page-title-main">TMEM260</span> Protein-coding gene in the species Homo sapiens

TMEM260 is a protein that in humans is encoded by the TMEM260 gene. The function of TMEM260 is not yet clearly understood. TMEM260 is also known as UPF0679, c14orf101, and FLJ0392.

<span class="mw-page-title-main">CFAP206</span> Protein-coding gene in the species Homo sapiens

Cilia And Flagella Associated Protein 206 (CFAP206) is a gene that in humans encodes a protein “DUF3508”. This protein has a function that is not currently very well understood. Other known aliases are “dJ382I10.1, UPF0704 Protein C6orf165.” In humans, the gene coding sequence is 56,501 base pairs long, with an mRNA of 2,215 base pairs, and a protein sequence of 622 amino acids. The C6orf165 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, frog, and more C6orf165 is rarely expressed in humans, with relatively high expression in brain, lungs (trachea) and testis. The molecular weight of UPF0704 is 71,193 Da and the PI is 6.38

<span class="mw-page-title-main">C1orf74</span> Protein-coding gene in the species Homo sapiens

UPF0739 protein C1orf74 is a protein that in humans is encoded by the C1orf74 gene.

<span class="mw-page-title-main">PRR29</span> Protein-coding gene in the species Homo sapiens

PRR29 is a protein encoded by the PRR29 gene located in humans on chromosome 17 at 17q23.

KIAA1107 is a protein that in humans is encoded by the KIAA1107 gene. KIAA1107 is a Serine-rich protein, whose expression was found to increase in white matter of Multiple Sclerosis brain lesions.

<span class="mw-page-title-main">FANCD2OS</span> Protein-coding gene in the species Homo sapiens

Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene. The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

<span class="mw-page-title-main">C12orf60</span> Protein-coding gene in the species Homo sapiens

Uncharacterized protein C12orf60 is a protein that in humans is encoded by the C12orf60 gene. The gene is also known as LOC144608 or MGC47869. The protein lacks transmembrane domains and helices, but it is rich in alpha-helices. It is predicted to localize in the nucleus.

<span class="mw-page-title-main">C8orf58</span> Protein-coding gene in the species Homo sapiens

Chromosome 8 open reading frame 58 is an uncharacterised protein that in humans is encoded by the C8orf58 gene. The protein is predicted to be localized in the nucleus.

<span class="mw-page-title-main">C19orf44</span> Mammalian protein found in Homo sapiens

Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein exists in other species besides human. The protein contains one domain of unknown function (DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, but also has significant expression in the thyroid and parathyroid. Other names for this protein include: LOC84167.

<span class="mw-page-title-main">C7orf61</span> Human gene

Uncharacterized protein chromosome 7 open reading frame 61 is an asparagine-poor protein in humans encoded by the c7orf61 gene. The protein function is relatively unknown and is highly conserved in mammals.

<span class="mw-page-title-main">C9orf50</span> Protein-coding gene in the species Homo sapiens

Chromosome 9 open reading frame 50 is a protein that in humans is encoded by the C9orf50 gene. C9orf50 has one other known alias, FLJ35803. In humans the gene coding sequence is 10,051 base pairs long, transcribing an mRNA of 1,624 bases that encodes a 431 amino acid protein.

<span class="mw-page-title-main">LSMEM2</span> Protein-coding gene in the species Homo sapiens

Leucine rich single-pass membrane protein 2 is a single-pass membrane protein rich in leucine, that in humans is encoded by the LSMEM2 gene. The LSMEM2 protein is conserved in mammals, birds, and reptiles. In humans, LSMEM2 is found to be highly expressed in the heart, skeletal muscle and tongue.

<span class="mw-page-title-main">C6orf136</span>

C6orf136 is a protein in humans encoded by the C6orf136 gene. The gene is conserved in mammals, mollusks, as well some porifera. While the function of the gene is currently unknown, C6orf136 has been shown to be hypermethylated in response to FOXM1 expression in Head Neck Squamous Cell Carcinoma (HNSCC) tissue cells. Additionally, elevated expression of C6orf136 has been associated with improved survival rates in patients with bladder cancer. C6orf136 has three known isoforms.

<span class="mw-page-title-main">C2orf72</span> Human protein encoding gene

C2orf72 is a gene in humans that encodes a protein currently named after its gene, C2orf72. It is also designated LOC257407 and can be found under GenBank accession code NM_001144994.2. The protein can be found under UniProt accession code A6NCS6.

<span class="mw-page-title-main">C11orf98</span> Protein-coding gene in the species Homo sapiens

C11orf98 is a protein-encoding gene on chromosome 11 in humans of unknown function. It is otherwise known as c11orf48. The gene spans the chromosomal locus from 62,662,817-62,665,210. There are 4 exons. It spans across 2,394 base pairs of DNA and produces an mRNA that is 646 base pairs long.

<span class="mw-page-title-main">C3orf38</span> An article about the uncharacterized gene C3orf38.

Chromosome 3 open reading frame 38 (C3orf38) is a protein which in humans is encoded by the C3orf38 gene.

<span class="mw-page-title-main">C1orf159</span> Protein encoded on a gene

C1orf159 is a protein that in human is encoded by the C1orf159 gene located on chromosome 1. This gene is also found to be an unfavorable prognosis marker for renal and liver cancer, and a favorable prognosis marker for urothelial cancer.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165120 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029784 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 5 "serine-rich single-pass membrane protein 1 [Homo sapiens]". Protein. NCBI. 26 August 2016. NP_660311.1. Retrieved 2016-12-16.
  6. "Showing 9.782 kbp from Chr7, positions 129,233,084 to 129,242,865". The Chromosome 7 Annotation Project. June 2004. Landmark or Region: Gene:C7orf45|NM_145268.2. Retrieved 2016-12-16.
  7. Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
  8. 1 2 3 "SSMEM1 serine rich single-pass membrane protein 1 [ Homo sapiens (human) ]". Gene. NCBI. 6 December 2016. 136263. Retrieved 2016-12-16.
  9. "Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1), mRNA". Nucleotide. NCBI. 26 August 2016. NM_145268.3. Retrieved 2016-12-16.
  10. "United States Patent: 8586006 - Organ-specific proteins and methods of their use".
  11. "Est Profile - Hs.351816". UniGene. NCBI. 2016.
  12. "GDS3834 / 4246". www.ncbi.nlm.nih.gov. Retrieved 2016-12-17.
  13. "Gene Detail :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2016-12-17.
  14. "SSMEM1 (human)". www.phosphosite.org. Retrieved 2016-12-17.