Scytonema varium

Scytonema varium
Scientific classification
Domain:	Bacteria
Kingdom:	Bacillati
Phylum:	Cyanobacteria
Class:	Cyanophyceae
Order:	Nostocales
Family:	Scytonemataceae
Genus:	Scytonema
Species:	S. varium
Binomial name
	Scytonema varium; Kützing, 1849

Last updated June 19, 2025

Scytonema varium is a cultured cyanobacterium of the genus Scytonema .^[1] It is one of many anti viral protein producing algae. In a similar manner to Cyanovirin-N from Nostoc Ellipsosporum and griffithsin from the red algae Griffithsia, Scytonema varium secretes the broad-spectrum antiviral protein scytovirin which can inactivate both the HIV virus,^[1] and Ebola virus,^[2] offering hope of treatment for many diseases with viral etiology (cause). It is currently being investigated as a topical microbicide for HIV prophylaxis.^[3]

References

1 2 Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC 2nd, Turpin J, Watson K, Buckheit RW Jr, Boyd MR (Mar 2003). "A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium". Biochemistry. 42 (9): 2578–84. doi:10.1021/bi0205698. PMID 12614152.
↑ Garrison, A. R.; Giomarelli, B. G.; Lear-Rooney, C. M.; Saucedo, C. J.; Yellayi, S; Krumpe, L. R.; Rose, M; Paragas, J; Bray, M; Olinger Jr, G. G.; McMahon, J. B.; Huggins, J; O'Keefe, B. R. (2014). "The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus". Antiviral Research. 112C: 1–7. doi:10.1016/j.antiviral.2014.09.012. PMC 4258435 . PMID 25265598.
↑ Xiong C; O'Keefe BR; Botos I; Wlodawer A; McMahon JB (Apr 2006). "Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium". Protein Expr Purif. 46 (2): 233–9. doi:10.1016/j.pep.2005.09.019. PMID 16289703.

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[bokesch-1] 1 2 Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC 2nd, Turpin J, Watson K, Buckheit RW Jr, Boyd MR (Mar 2003). "A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium". Biochemistry. 42 (9): 2578–84. doi:10.1021/bi0205698. PMID 12614152.

[2] Garrison, A. R.; Giomarelli, B. G.; Lear-Rooney, C. M.; Saucedo, C. J.; Yellayi, S; Krumpe, L. R.; Rose, M; Paragas, J; Bray, M; Olinger Jr, G. G.; McMahon, J. B.; Huggins, J; O'Keefe, B. R. (2014). "The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus". Antiviral Research. 112C: 1–7. doi:10.1016/j.antiviral.2014.09.012. PMC 4258435 . PMID 25265598.

[3] Xiong C; O'Keefe BR; Botos I; Wlodawer A; McMahon JB (Apr 2006). "Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium". Protein Expr Purif. 46 (2): 233–9. doi:10.1016/j.pep.2005.09.019. PMID 16289703.

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