Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene. [4]
Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene. [4]
Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.
This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].
Semaphorins are a class of secreted and membrane proteins that were originally identified as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. Semaphorins are usually cues to deflect axons from inappropriate regions, especially important in the neural system development. The major class of proteins that act as their receptors are called plexins, with neuropilins as their co-receptors in many cases. The main receptors for semaphorins are plexins, which have established roles in regulating Rho-family GTPases. Recent work shows that plexins can also influence R-Ras, which, in turn, can regulate integrins. Such regulation is probably a common feature of semaphorin signalling and contributes substantially to our understanding of semaphorin biology.
CD46 complement regulatory protein also known as CD46 and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.
A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.
Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.
Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.
Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.
Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.
Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.
Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.
Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.
Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.
Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.
Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.
Semaphorin 7A, GPI membrane anchor (SEMA7A) also known as CD108, is a human gene.
Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.
Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.
Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.
Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.
Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene.
Semaphorin-4G is a protein that in humans is encoded by the SEMA4G gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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