Small Cajal body specific RNA 14

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Small Cajal body specific RNA 14
RF00582.jpg
Predicted secondary structure and sequence conservation of SCARNA14
Identifiers
SymbolSCARNA14
Alt. SymbolssnoU100
Rfam RF00582
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO GO:0006396 GO:0015030 GO:0005730
SO SO:0000275
PDB structures PDBe

In molecular biology, Small Cajal body specific RNA 14 (also known as scaRNA14 or U100) is a small nucleolar RNA found in Cajal bodies.

scaRNAs are a specific class of small nucleolar RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1] [2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs. [3]

U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 which is also included in this family. [4] U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7. [5]

Related Research Articles

In molecular biology, Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs, which are associated with methylation, and the H/ACA box snoRNAs, which are associated with pseudouridylation. SnoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.

<span class="mw-page-title-main">Small Cajal body specific RNA 11</span>

In molecular biology, Small Cajal body specific RNA 11 is a small nucleolar RNA found in Cajal bodies.

<span class="mw-page-title-main">Small Cajal body specific RNA 13</span>

In molecular biology, Small Cajal body specific RNA 13 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 15</span>

Small Cajal body specific RNA 15 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 16</span>

Small Cajal body specific RNA 16 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 23</span>

Small Cajal body specific RNA 23 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 24</span>

Small Cajal body specific RNA 24 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U6 spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 25</span>

Small Cajal body specific RNA 25 is a scaRNA, which are a class of ncRNAs characterised as small nuclear RNAs localised to the Cajal bodies.

<span class="mw-page-title-main">Small Cajal body specific RNA 4</span>

In molecular biology, small Cajal body specific RNA 4 is believed to be a guide RNA of the H/ACA box class, since it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs, and is found associated with GAR1. In particular, ACA26 is predicted to guide the pseudouridylation of residues U39 and U41 in U2 snRNA. Such scaRNAs are a specific class of small nuclear RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

<span class="mw-page-title-main">Small Cajal body specific RNA 6</span>

Small Cajal body specific RNA 6 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U5 spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 8</span>

Small Cajal body specific RNA 8 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORA26</span> Member of the H/ACA class of small nucleolar RNA

In molecular biology, SNORA26 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

<span class="mw-page-title-main">Small nucleolar RNA SNORA30</span> Non-coding RNA molecule which functions in the biogenesis of other small nuclear RNAs

In molecular biology, SNORA30 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of eukaryotic cells. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA' as it 'guides' the modification process.

<span class="mw-page-title-main">Small nucleolar RNA SNORA44</span> Non-coding RNA molecule which functions in the biogenesis of other small nuclear RNAs

In molecular biology, Small nucleolar RNA SNORA44 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

<span class="mw-page-title-main">Small nucleolar RNA SNORA57</span>

In molecular biology, Small nucleolar RNA SNORA57 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

<span class="mw-page-title-main">Small nucleolar RNA SNORA58</span>

In molecular biology, Small nucleolar RNA SNORA58 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

<span class="mw-page-title-main">Small nucleolar RNA SNORA65</span>

In molecular biology, SNORA65 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

<span class="mw-page-title-main">Small Cajal body-specific RNA</span>

Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins. ScaRNAs guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

<span class="mw-page-title-main">Small Cajal body specific RNA 20</span>

In molecular biology, Small Cajal body specific RNA 20 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

<span class="mw-page-title-main">Small Cajal body specific RNA 21</span>

In molecular biology, Small Cajal body specific RNA 21 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

References

  1. ↑ Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–56. doi:10.1093/emboj/21.11.2746. PMC   126017 . PMID   12032087.
  2. ↑ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.
  3. ↑ Vitali P, Royo H, Seitz H, Bachellerie JP, Hüttenhofer A, Cavaillé J (November 2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Research. 31 (22): 6543–51. doi:10.1093/nar/gkg849. PMC   275545 . PMID   14602913.
  4. ↑ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC   125495 . PMID   11387227.
  5. ↑ Schattner P, Barberan-Soler S, Lowe TM (January 2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC   1370881 . PMID   16373490.
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