Small Cajal body specific RNA 15

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Small Cajal body specific RNA 15
RF00426.jpg
Predicted secondary structure and sequence conservation of SCARNA15
Identifiers
SymbolSCARNA15
Alt. SymbolssnoACA45
Rfam RF00426
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO GO:0006396 GO:0015030 GO:0005730
SO SO:0000275
PDB structures PDBe

Small Cajal body specific RNA 15 (also known as SCARNA15 or ACA45) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1]

ACA45 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1. [2] ACA45 is predicted to guide the pseudouridylation of residue U37 of the U2 spliceosomal snRNA. [3]

It has been shown that human ACA45 can be processed into a 21 nucleotides long mature miRNA by the RNAse III family endoribonuclease dicer. [4] This snoRNA product has previously been identified as mmu-miR-1839 [5] and was shown to be processed independent of the other miRNA generating endoribonuclease drosha. [6]

Related Research Articles

Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs, which are associated with methylation, and the H/ACA box snoRNAs, which are associated with pseudouridylation. SnoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.

Small Cajal body specific RNA 11

In molecular biology, Small Cajal body specific RNA 11 is a small nucleolar RNA found in Cajal bodies.

Small Cajal body specific RNA 13

In molecular biology, Small Cajal body specific RNA 13 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.

Small Cajal body specific RNA 14

In molecular biology, Small Cajal body specific RNA 14 is a small nucleolar RNA found in Cajal bodies.

Small Cajal body specific RNA 16

Small Cajal body specific RNA 16 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.

Small Cajal body specific RNA 23

Small Cajal body specific RNA 23 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.

Small Cajal body specific RNA 24

Small Cajal body specific RNA 24 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U6 spliceosomal RNA.

Small Cajal body specific RNA 4

In molecular biology, small Cajal body specific RNA 4 is believed to be a guide RNA of the H/ACA box class, since it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs, and is found associated with GAR1. In particular, ACA26 is predicted to guide the pseudouridylation of residues U39 and U41 in U2 snRNA. Such scaRNAs are a specific class of small nuclear RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

Small Cajal body specific RNA 6

Small Cajal body specific RNA 6 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U5 spliceosomal RNA.

Small Cajal body specific RNA 8

Small Cajal body specific RNA 8 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA.

Small nucleolar RNA SNORA43

Small nucleolar RNA SNORA43 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

Small nucleolar RNA SNORA46

Small nucleolar RNA SNORA46 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA46 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA46 is predicted to guide the pseudouridylation of U649 of 18S ribosomal RNA (rRNA). Pseudouridylation is the isomerisation of the nucleoside uridine to the different isomeric form pseudouridine.

Small nucleolar RNA SNORA50

Small nucleolar RNA SNORA50 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA50 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA50 is predicted to guide the pseudouridylation of U34 and U105 of 18S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.

Small nucleolar RNA SNORA55

Small nucleolar RNA SNORA55 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA55 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA55 is predicted to guide the pseudouridylation of U36 of 18S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.

Small nucleolar RNA SNORA56

Small nucleolar RNA SNORA56 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA56 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA56 is predicted to guide the pseudouridylation of U1664 of 28S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.

Small Cajal body-specific RNA

Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins. ScaRNAs guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

Small Cajal body specific RNA 20

In molecular biology, Small Cajal body specific RNA 20 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

Small Cajal body specific RNA 21

In molecular biology, Small Cajal body specific RNA 21 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

Small nucleolar RNA SNORA77

Small nucleolar RNA SNORA77 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

Small nucleolar RNA SNORA79

Small nucleolar RNA SNORA79 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

References

  1. ↑ Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–56. doi:10.1093/emboj/21.11.2746. PMC   126017 . PMID   12032087.
  2. ↑ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC   480876 . PMID   15199136.
  3. ↑ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.
  4. ↑ Ender C, Krek A, Friedländer MR, Beitzinger M, Weinmann L, Chen W, Pfeffer S, Rajewsky N, Meister G (November 2008). "A human snoRNA with microRNA-like functions". Molecular Cell. 32 (4): 519–28. doi: 10.1016/j.molcel.2008.10.017 . PMID   19026782.
  5. ↑ "mmu-miR-1839". MiRBase.
  6. ↑ Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R (October 2008). "Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs". Genes & Development. 22 (20): 2773–85. doi:10.1101/gad.1705308. PMC   2569885 . PMID   18923076.
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