Small Cajal body specific RNA 21 | |
---|---|
Predicted secondary structure and sequence conservation of SCARNA21 | |
Identifiers | |
Symbol | SCARNA21 |
Rfam | RF00602 |
Other data | |
RNA type | Gene; snRNA; snoRNA; scaRNA |
Domain(s) | Eukaryota |
GO | 0006396 0015030 0005730 |
SO | 0000275 |
PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 21 (also known as scaRNA21 or ACA68) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1]
ACA68 (SCARNA21) is a member of the H/ACA box class of snoRNAs that guide the sites of modification of uridines to pseudouridines. This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis. [2] ACA68 is proposed to guide the pseudouridylation of residue U19 in U12 snRNA. [3]
Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs, which are associated with methylation, and the H/ACA box snoRNAs, which are associated with pseudouridylation. SnoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.
In molecular biology, Small Cajal body specific RNA 11 is a small nucleolar RNA found in Cajal bodies.
In molecular biology, Small Cajal body specific RNA 13 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.
In molecular biology, Small Cajal body specific RNA 14 is a small nucleolar RNA found in Cajal bodies.
Small Cajal body specific RNA 15 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.
Small Cajal body specific RNA 16 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.
Small Cajal body-specific RNA 17 is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
small Cajal body-specific RNA 18 is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
Small Cajal body specific RNA 23 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U1 spliceosomal RNA.
Small Cajal body specific RNA 24 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U6 spliceosomal RNA.
Small Cajal body specific RNA 25 is a scaRNA, which are a class of ncRNAs characterised as small nuclear RNAs localised to the Cajal bodies.
In molecular biology, small Cajal body specific RNA 4 is believed to be a guide RNA of the H/ACA box class, since it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs, and is found associated with GAR1. In particular, ACA26 is predicted to guide the pseudouridylation of residues U39 and U41 in U2 snRNA. Such scaRNAs are a specific class of small nuclear RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
Small Cajal body specific RNA 6 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U5 spliceosomal RNA.
Small Cajal body specific RNA 8 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA.
In molecular biology, small nucleolar RNA SNORA10 and small nuclear RNA SNORA64 are homologous members of the H/ACA class of small nucleolar RNA (snoRNA). This family of ncRNAs involved in the maturation of ribosomal RNA. snoRNA in this family act as guides in the modification of uridines to pseudouridines. This family includes the human snoRNAs U64 and ACA10 and mouse MBI-29.
Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins. ScaRNAs guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
In molecular biology, SNORA76 is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, Small Cajal body specific RNA 20 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.
Small nucleolar RNA SNORA77 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).
Small nucleolar RNA SNORA79 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).
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