Small Cajal body specific RNA 18

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small Cajal body-specific RNA 18
RF00283.jpg
Predicted secondary structure and sequence conservation of SCARNA18
Identifiers
SymbolSCARNA18
Alt. SymbolsU91
Rfam RF00283
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO GO:0006396 GO:0015030 GO:0005730
SO SO:0000275
PDB structures PDBe

small Cajal body-specific RNA 18 (also known as U91 or U4-8) is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1]

This snoRNA U91 appears to be belong to the C/D box class of snoRNAs. [2] It was identified by Darzacq [1] and is predicted to guide the 2'O-ribose methylation of U4 snRNA C8. This C/D domain was later found associated in tandem with another C/D box domain U12-22. Both the doublet (U12-22/U4-8) and singlet (U4-8) forms of this snRNA have been purified from Hela cells. [1] The doublet form U12-22/U4-8 has been shown to localise to the nucleoplasm and is proposed to reside in the Cajal bodies whereas the U4-8 single domain appears to accumulate in the nucleolus. [3] In humans the genomic location of U12-88/U4-8 is intergenic and the purified transcript has been shown to possess a methylated guanosine cap suggesting it is independently transcribed by RNA pol II. [3]

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Small Cajal body-specific RNA

Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins. ScaRNAs guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

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In molecular biology, Small Cajal body specific RNA 20 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

Small Cajal body specific RNA 21

In molecular biology, Small Cajal body specific RNA 21 is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

References

  1. 1 2 3 Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21 (11): 2746–56. doi:10.1093/emboj/21.11.2746. PMC   126017 . PMID   12032087.
  2. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology . 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  3. 1 2 Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research . 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.


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