Forskolin (coleonol) is a labdane diterpene produced by the plant Coleus barbatus. Other names include pashanabhedi, Indian coleus, makandi, HL-362, mao hou qiao rui hua. As with other members of the large diterpene class of plant metabolites, forskolin is derived from geranylgeranyl pyrophosphate (GGPP). Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring. Forskolin is commonly used in laboratory research to increase levels of cyclic AMP by stimulation of adenylate cyclase.
Hopanoids are a diverse subclass of triterpenoids with the same hydrocarbon skeleton as the compound hopane. This group of pentacyclic molecules therefore refers to simple hopenes, hopanols and hopanes, but also to extensively functionalized derivatives such as bacteriohopanepolyols (BHPs) and hopanoids covalently attached to lipid A.
Lanosterol synthase is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by the LSS gene.
In enzymology, an ent-copalyl diphosphate synthase is an enzyme that catalyzes the chemical reaction:
The enzyme ent-kaurene synthase catalyzes the chemical reaction
Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene.
Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.
Momilactone B is an allelopathic agent produced from the roots of rice. It has been shown to be produced in high concentrations by the roots of rice seedlings. The production of momilactone B has also been induced in response to infection by blast fungus or irradiated with UV light. More recently it has been shown to be a potential chemotherapeutic agent against human colon cancer.
In molecular biology, this protein domain belongs to the terpene synthase family (TPS). Its role is to synthesize terpenes, which are part of primary metabolism, such as sterols and carotene, and also part of the secondary metabolism. This entry will focus on the N terminal domain of the TPS protein.
In molecular biology, this protein domain belongs to the terpene synthase family (TPS). Its role is to synthesize terpenes, which are part of primary metabolism, such as sterols and carotene, and also part of the secondary metabolism. This entry will focus on the C terminal domain of the TPS protein.
ent-Sandaracopimaradiene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming]. This enzyme catalyses the following chemical reaction
ent-Pimara-8(14),15-diene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming]. This enzyme catalyses the following chemical reaction
Stemar-13-ene synthase is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming). This enzyme catalyses the following chemical reaction
Stemod-13(17)-ene synthase is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction
Elisabethatriene synthase is an enzyme with systematic name geranylgeranyl-diphosphate diphosphate-lyase (elisabethatriene-forming). This enzyme catalyses the following chemical reaction
Labdatriene synthase is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction
ent-Isokaurene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction
(+)-Car-3-ene synthase is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-car-3-ene-forming]. This enzyme catalyses the following chemical reaction
(–)-α-Pinene synthase is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (–)-α-pinene-forming]. This enzyme catalyses the following chemical reaction
Akhilesh Kumar Tyagi is an Indian plant biologist and the former director of National Institute of Plant Genome Research. Known for his studies on plant genomics and biotechnology, Tyagi is an elected fellow of all the three major Indian science academies namely Indian Academy of Sciences, Indian National Science Academy and National Academy of Sciences, India as well as The World Academy of Sciences and the National Academy of Agricultural Sciences. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences in 1999.
