Stephen Boppart

Last updated
Professor
Stephen A. Boppart
Ph.D., M.D.
Boppart-Lab.jpg
Professor Stephen Boppart sitting in front of optical table in the Optical Coherence Technology (OCT) laboratory at the Beckman Institute for Advance Science and Technology on the University of Illinois Urbana-Champaign campus
Born1968
NationalityAmerican
Alma mater
Awards
Scientific career
Fields Biophotonics
Institutions
Thesis Surgical diagnostics, guidance, and intervention using optical coherence tomography  (1998)
Doctoral advisor James Fujimoto
Other academic advisorsBruce Wheeler
Website biophotonics.illinois.edu

Stephen A. Boppart is a principal investigator at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign, where he holds an Abel Bliss Professorship in engineering. [1] He is a faculty member in the departments of electrical and computer engineering, bioengineering, and internal medicine. His research focus is biophotonics, where he has pioneered new optical imaging technologies in the fields of optical coherence tomography, multi-photon microscopy, and computational imaging. [2]

Contents

Background and education

Boppart was born in the small farming community of Harvard, Illinois. [3] In 1990, he received his B.S. degree from the University of Illinois at Urbana-Champaign (UIUC) in electrical engineering, with an option in bioengineering. [4] In 1991, he received his M.S. degree in electrical engineering from UIUC. His master's research involved the development of multielectrode arrays under Professor Bruce Wheeler. From 1991 to 1993, he developed national laser safety standards at the Air Force Research Laboratory in San Antonio, Texas. He then returned to graduate school to pursue both the Ph.D. and M.D. degrees under a joint program between the Massachusetts Institute of Technology (MIT) and Harvard Medical School. He received his Ph.D. in medical and electrical engineering in 1998 under the direction of James Fujimoto, and completed his M.D. in 2000. While at MIT, he was involved in the invention and early development of optical coherence tomography (OCT). [5] [6]

Research

Boppart started the Biophotonics Imaging Laboratory at UIUC in 2000, an interdisciplinary research group working at the intersection of engineering, medicine, and biology. The research focuses on the development of biophotonics for translational medicine in primary care and oncology. Building upon the development of OCT in his graduate studies, Boppart expanded OCT to new application areas. OCT was used to image the tympanic membrane (eardrum) to determine the presence of biofilm, a complicating factor in ear infections. [7] [8] He also developed OCT for intraoperative breast cancer imaging to determine the status of the resection margin. [9] [10]

At UIUC, his research interests expanded to include nonlinear optical microscopy. He developed nonlinear interferometric vibrational imaging, a variation of CARS microscopy, for imaging cancer resection margins. [11] He also pioneered multimodal-multiphoton microscopy, the combination of several nonlinear optical imaging modalities into a single imaging system. [12] [13] These nonlinear optical imaging technologies were enabled by the development of an optical fiber-based supercontinuum laser source. In 2017, Boppart demonstrated coherent control of neurons. [14] [15]

Boppart applied computational imaging to coherent optical microscopy by solving the inverse problem for OCT. [16] [17] [18] This allows for three-dimensional imaging with extended depth-of-field and digital correction of optical aberrations. [19] [20] [21]

Administration and entrepreneurship

From 2006 to 2008, Boppart was the founding director of the Mills Breast Cancer Institute at Carle Foundation Hospital. [22] In 2011, he headed the Strategic Initiative on Imaging at UIUC. [23] He was also heavily involved in the founding of the engineering-based Carle Illinois College of Medicine in 2015. [24] [25]

Multiple startup companies have been formed from Boppart's research. In 2011, Diagnostic Photonics, Inc. was launched which develops a handheld probe for imaging the breast cancer resection margin. [26] In 2013, PhotoniCare was formed to commercialize a handheld probe for imaging biofilms in the middle ear. [27]

Awards and honors

SPIE, Biophotonics Technology Innovator Award, 2019 [28]

Massachusetts Institute of Technology, Technology Review Top 100 Young Innovators Award [29]

National Science Foundation Career Award [30]

Hans Sigrist Prize, 2012 [31]

Abel Bliss Professorship in Engineering, 2011 [3] [32]

Paul F. Forman Team Engineering Excellence Award, 2009 [33]

Fellow, Optical Society of America

Fellow, SPIE

Fellow, Institute of Electrical and Electronics Engineers

Fellow, American Association for the Advancement of Science

Fellow, American Institute for Medical and Biological Engineering

Fellow, Biomedical Engineering Society

Related Research Articles

The term biophotonics denotes a combination of biology and photonics, with photonics being the science and technology of generation, manipulation, and detection of photons, quantum units of light. Photonics is related to electronics and photons. Photons play a central role in information technologies, such as fiber optics, the way electrons do in electronics.

<span class="mw-page-title-main">Optical coherence tomography</span> Imaging technique

Optical coherence tomography (OCT) is an imaging technique that uses interferometry with short-coherence-length light to obtain micrometer-level depth resolution and uses transverse scanning of the light beam to form two- and three-dimensional images from light reflected from within biological tissue or other scattering media. Short-coherence-length light can be obtained using a superluminescent diode (SLD) with a broad spectral bandwidth or a broadly tunable laser with narrow linewidth. The first demonstration of OCT imaging was published by a team from MIT and Harvard Medical School in a 1991 article in the journal Science. The article introduced the term "OCT" to credit its derivation from optical coherence-domain reflectometry, in which the axial resolution is based on temporal coherence. The first demonstrations of in vivo OCT imaging quickly followed.

<span class="mw-page-title-main">Bruce J. Tromberg</span> American chemist

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An ultrashort pulse laser is a laser that emits ultrashort pulses of light, generally of the order of femtoseconds to one picosecond. They are also known as ultrafast lasers owing to the speed at which pulses "turn on" and "off"—not to be confused with the speed at which light propagates, which is determined by the properties of the medium, particularly its index of refraction, and can vary as a function of field intensity and wavelength.

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James G. Fujimoto is Elihu Thomson Professor of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology (MIT) and a visiting professor of ophthalmology at Tufts University School of Medicine, Boston, Massachusetts.

Lihong V. Wang is the Bren Professor of Medical Engineering and Electrical Engineering at the Andrew and Peggy Cherng Department of Medical Engineering at California Institute of Technology and was formerly the Gene K. Beare Distinguished Professorship of Biomedical Engineering at Washington University in St. Louis. Wang is known for his contributions to the field of Photoacoustic imaging technologies. Wang was elected as the member of National Academy of Engineering (NAE) in 2018.

<span class="mw-page-title-main">Endoscopic optical coherence tomography imaging</span> History, technology, medical applications and recent developments of intravascular OCT

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Seok-Hyun "Andy" Yun is a scientist and technologist at Harvard University in Cambridge, Massachusetts. He was born and raised in South Korea and received his B.S. (1991), M.S., and Ph.D. (1997) in Physics from KAIST in Korea. His dissertation research in fiber optics led to a venture-funded startup in San Jose, CA, where he was a founding member and manager. He joined the Wellman Center for Photomedicine (Dermatology) at Massachusetts General Hospital and Harvard Medical School in 2003 and is as of January 2017 a Professor, MGH Research Scholar, and the Director of the Harvard-MIT Summer Institute for Biomedical Optics. He is a recipient of the 2016 NIH Director's Pioneer Award.

Elizabeth M. C. Hillman is a British-born academic who is Professor of Biomedical Engineering and Radiology at Columbia University. She was awarded the 2011 Adolph Lomb Medal from The Optical Society and the 2018 SPIE Biophotonics Technology Innovator Award.

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<span class="mw-page-title-main">Christine P. Hendon</span> American electrical engineer and computer scientist

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References

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