Stephen L. Hoffman

Last updated
Stephen L. Hoffman
Headshot, Dr. Stephen L Hoffman.png
Dr. Hoffman in 2024
Born
Stephen L. Hoffman

(1948-07-31) July 31, 1948 (age 77)
Alma mater
Scientific career
Fields Malaria, Vaccinology, Global Health
Institutions
Military career
Allegiance United States
Branch United States Navy
Years of service1980–2001
RankCaptain
Awards

Early life and education

Hoffman was raised initially in Belmar and subsequently in Ocean Township, Monmouth County, New Jersey. [1] He graduated from Asbury Park High School in 1966, [2] received a BA in political science from the University of Pennsylvania in 1970, an MD from Cornell University Medical College (now Weill Cornell Medicine) in 1975, [3] and a Diploma in Tropical Medicine and Hygiene from the London School of Hygiene and Tropical Medicine in 1978. [4] Additionally in 1978, he completed a residency in Family Medicine at the University of California San Diego. [5] He is board certified in Family Medicine and received a Certificate of Knowledge in Clinical Tropical Medicine and Travelers Health in 1998, and a Doctor of Science (DSc), honoris causa from Monmouth University in 2006. [6] [5]

Professional career

Work experience

After completing his residency in 1978, Hoffman was co-founder and director of the Tropical Medicine and Travelers clinic at University Hospital, University of California, San Diego, an adjunct clinical faculty member, and an emergency room physician. [5] In 1980, Hoffman was commissioned as a medical officer in the United States Navy and stationed in Jakarta, Indonesia at the Naval Medical Research Unit Two-Jakarta Detachment where he was the director of the Department of Clinical Investigation and Epidemiology through 1984. His initial focus was on treatment of severe typhoid fever. He proposed and studied the use of high dose dexamethasone in the treatment of severe typhoid fever, which reduced the typhoid fever death rate by more than 80 percent. [7] He also conducted research throughout the Indonesian archipelago on cholera, filariasis, and malaria. [5] [3] In 1987, Hoffman returned to Bethesda, MD, and served as the director of the Malaria Program at the Naval Medical Research Institute (later Naval Medical Research Center) until 2001. Hoffman and his team worked on identifying the targets and mechanisms of protective immunity against malaria and malaria vaccine development. They were the first in the world to test a DNA vaccine in normal humans and demonstrate that DNA vaccines elicited killer T cell responses. [8] Hoffman also led the team that sequenced the Plasmodium falciparum genome. [9]

After retiring from the Navy, Hoffman spent two years as senior vice president of biologics at Celera Genomics, the company that sequenced the human genome. Hoffman worked with utilizing human genomics and proteomics to develop immunotherapies and vaccines against cancer and to establish the potential for the field of personalized medicine. He also organized the sequencing of the genome of Anopheles gambiae . [10]

In 2003 Hoffman founded Sanaria Inc. to develop whole sporozoite malaria vaccines and has since been the chief executive and scientific officer of Sanaria Inc. [11]

Contributions to science and technology

Hoffman has over 500 scientific publications. He has made major contributions in the following areas.

Awards and distinctions

Awards

Memberships

Personal life

Hoffman is married to B. Kim Lee Sim, PhD, a molecular biologist, who was the founder and president of Protein Potential LLC and is current executive vice president of Sanaria Inc. [34] [45] They have three children (Alexander [JD], [46] Seth [MD], [47] and Benjamin [MD, PhD] [48] ).

Selected publications

References

  1. Mancuso, Donna. "'Cunning' parasite thwarts scientists' tries for malaria cure", Asbury Park Press , January 14, 1992. Accessed July 12, 2022, via Newspapers.com. "'We need new and better drugs to treat people, better methods of controlling mosquitoes and the infrastructure to deliver the technology,' said Hoffman, who was born in Belmar and grew up in Ocean Township."
  2. Stephen L. Hoffman, Asbury Park High School Distinguished Alumni Hall of Fame. Accessed July 12, 2022. "Class: 1966 Inducted: 2007"
  3. 1 2 3 "Dr. Stephen Hoffman". WCM Newsroom. Retrieved 2022-02-07.
  4. "COVID-19 Alumni Stories: Dr Stephen Hoffmann". LSHTM. Retrieved 2022-03-24.
  5. 1 2 3 4 Hoffman, Stephen L. (2002-07-01). "Presidential address: The American Society of Tropical Medicine and Hygiene in the last half century: from apparent anachronism to international leader and innovator" . The American Journal of Tropical Medicine and Hygiene. 67 (1): 1–7. doi: 10.4269/ajtmh.2002.67.1 . PMID   12363050.
  6. Hoffman, Stephen (2006). "Monmouth Calendar of Events" (PDF). Monmouth.edu. Retrieved 2022-02-02.
  7. 1 2 Hoffman, S. L.; Punjabi, N. H.; Kumala, S.; Moechtar, M. A.; Pulungsih, S. P.; Rivai, A. R.; Rockhill, R. C.; Woodward, T. E.; Loedin, A. A. (1984-01-12). "Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone". The New England Journal of Medicine. 310 (2): 82–88. doi:10.1056/NEJM198401123100203. ISSN   0028-4793. PMID   6361558.
  8. 1 2 3 4 Wang, R.; Doolan, D. L.; Le, T. P.; Hedstrom, R. C.; Coonan, K. M.; Charoenvit, Y.; Jones, T. R.; Hobart, P.; Margalith, M.; Ng, J.; Weiss, W. R. (1998-10-16). "Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine". Science. 282 (5388): 476–480. Bibcode:1998Sci...282..476W. doi:10.1126/science.282.5388.476. ISSN   0036-8075. PMID   9774275.
  9. "Marine Biological Laboratory". comm.archive.mbl.edu. Retrieved 2022-02-07.
  10. 1 2 3 Holt, Robert A.; Subramanian, G. Mani; Halpern, Aaron; Sutton, Granger G.; Charlab, Rosane; Nusskern, Deborah R.; Wincker, Patrick; Clark, Andrew G.; Ribeiro, José M. C.; Wides, Ron; Salzberg, Steven L. (2002-10-04). "The genome sequence of the malaria mosquito Anopheles gambiae". Science. 298 (5591): 129–149. Bibcode:2002Sci...298..129H. doi:10.1126/science.1076181. ISSN   1095-9203. PMID   12364791. S2CID   4512225.
  11. "SANARIA INC. | SBIR.gov". www.sbir.gov. Retrieved 2022-03-10.
  12. Punjabi, N. H.; Hoffman, S. L.; Edman, D. C.; Sukri, N.; Laughlin, L. W.; Pulungsih, S. P.; Rivai, A. R.; Sututo, null; Moechtar, A.; Woodward, T. E. (August 1988). "Treatment of severe typhoid fever in children with high dose dexamethasone". The Pediatric Infectious Disease Journal. 7 (8): 598–600. doi: 10.1097/00006454-198808000-00002 . ISSN   0891-3668. PMID   3050856.
  13. 1 2 Hoffman, S. L.; Oster, C. N.; Plowe, C. V.; Woollett, G. R.; Beier, J. C.; Chulay, J. D.; Wirtz, R. A.; Hollingdale, M. R.; Mugambi, M. (1987-08-07). "Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications". Science. 237 (4815): 639–642. Bibcode:1987Sci...237..639H. doi:10.1126/science.3299709. ISSN   0036-8075. PMID   3299709.
  14. 1 2 Hoffman, Stephen L.; Isenbarger, Daniel; Long, Gary W.; Sedegah, Martha; Szarfman, Ana; Waters, Leslie; Hollingdale, Michael R.; Van Der Meide, Peter H.; Finbloom, David S.; Ballou, W. Ripley (1989). "Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes" . Science. 244 (4908): 1078–1081. Bibcode:1989Sci...244.1078H. doi:10.1126/science.2524877. ISSN   0036-8075. JSTOR   1704001. PMID   2524877.
  15. 1 2 Malik, A.; Egan, J. E.; Houghten, R. A.; Sadoff, J. C.; Hoffman, S. L. (1991-04-15). "Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein". Proceedings of the National Academy of Sciences of the United States of America. 88 (8): 3300–3304. Bibcode:1991PNAS...88.3300M. doi: 10.1073/pnas.88.8.3300 . ISSN   0027-8424. PMC   51434 . PMID   1707538.
  16. 1 2 Doolan, D. L.; Hoffman, S. L. (2000-08-01). "The complexity of protective immunity against liver-stage malaria". Journal of Immunology. 165 (3): 1453–1462. doi: 10.4049/jimmunol.165.3.1453 . ISSN   0022-1767. PMID   10903750. S2CID   520874.
  17. 1 2 Sedegah, M.; Hedstrom, R.; Hobart, P.; Hoffman, S. L. (1994-10-11). "Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein". Proceedings of the National Academy of Sciences of the United States of America. 91 (21): 9866–9870. Bibcode:1994PNAS...91.9866S. doi: 10.1073/pnas.91.21.9866 . ISSN   0027-8424. PMC   44918 . PMID   7937907.
  18. 1 2 Sedegah, M.; Jones, T. R.; Kaur, M.; Hedstrom, R.; Hobart, P.; Tine, J. A.; Hoffman, S. L. (1998-06-23). "Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine". Proceedings of the National Academy of Sciences of the United States of America. 95 (13): 7648–7653. Bibcode:1998PNAS...95.7648S. doi: 10.1073/pnas.95.13.7648 . ISSN   0027-8424. PMC   22711 . PMID   9636204.
  19. 1 2 Gardner, M. J.; Tettelin, H.; Carucci, D. J.; Cummings, L. M.; Aravind, L.; Koonin, E. V.; Shallom, S.; Mason, T.; Yu, K.; Fujii, C.; Pederson, J. (1998-11-06). "Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum". Science. 282 (5391): 1126–1132. doi:10.1126/science.282.5391.1126. ISSN   0036-8075. PMID   9804551.
  20. 1 2 Hoffman, Stephen L.; Subramanian, G. Mani; Collins, Frank H.; Venter, J. Craig (2002-02-07). "Plasmodium, human and Anopheles genomics and malaria". Nature. 415 (6872): 702–709. doi: 10.1038/415702a . ISSN   0028-0836. PMID   11832959. S2CID   4414185.
  21. 1 2 Hoffman, Stephen L.; Goh, Lucy M. L.; Luke, Thomas C.; Schneider, Imogene; Le, Thong P.; Doolan, Denise L.; Sacci, John; de la Vega, Patricia; Dowler, Megan; Paul, Chris; Gordon, Daniel M. (2002-04-15). "Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites". The Journal of Infectious Diseases. 185 (8): 1155–1164. doi: 10.1086/339409 . ISSN   0022-1899. PMID   11930326.
  22. 1 2 Epstein, J. E.; Tewari, K.; Lyke, K. E.; Sim, B. K. L.; Billingsley, P. F.; Laurens, M. B.; Gunasekera, A.; Chakravarty, S.; James, E. R.; Sedegah, M.; Richman, A. (2011-10-28). "Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity". Science. 334 (6055): 475–480. Bibcode:2011Sci...334..475E. doi: 10.1126/science.1211548 . ISSN   1095-9203. PMID   21903775. S2CID   206536528.
  23. 1 2 Seder, Robert A.; Chang, Lee-Jah; Enama, Mary E.; Zephir, Kathryn L.; Sarwar, Uzma N.; Gordon, Ingelise J.; Holman, LaSonji A.; James, Eric R.; Billingsley, Peter F.; Gunasekera, Anusha; Richman, Adam (2013-09-20). "Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine". Science. 341 (6152): 1359–1365. Bibcode:2013Sci...341.1359S. doi: 10.1126/science.1241800 . ISSN   1095-9203. PMID   23929949. S2CID   22462258.
  24. 1 2 Mordmüller, Benjamin; Surat, Güzin; Lagler, Heimo; Chakravarty, Sumana; Ishizuka, Andrew S.; Lalremruata, Albert; Gmeiner, Markus; Campo, Joseph J.; Esen, Meral; Ruben, Adam J.; Held, Jana (2017-02-23). "Sterile protection against human malaria by chemoattenuated PfSPZ vaccine". Nature. 542 (7642): 445–449. Bibcode:2017Natur.542..445M. doi:10.1038/nature21060. ISSN   1476-4687. PMC   10906480 . PMID   28199305. S2CID   205253429.
  25. 1 2 3 Sissoko, Mahamadou S.; Healy, Sara A.; Katile, Abdoulaye; Omaswa, Freda; Zaidi, Irfan; Gabriel, Erin E.; Kamate, Bourama; Samake, Yacouba; Guindo, Merepen A.; Dolo, Amagana; Niangaly, Amadou (May 2017). "Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial". The Lancet. Infectious Diseases. 17 (5): 498–509. doi:10.1016/S1473-3099(17)30104-4. ISSN   1474-4457. PMC   6803168 . PMID   28216244.
  26. 1 2 Mwakingwe-Omari, Agnes; Healy, Sara A.; Lane, Jacquelyn; Cook, David M.; Kalhori, Sahand; Wyatt, Charles; Kolluri, Aarti; Marte-Salcedo, Omely; Imeru, Alemush; Nason, Martha; Ding, Lei K. (July 2021). "Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity". Nature. 595 (7866): 289–294. Bibcode:2021Natur.595..289M. doi:10.1038/s41586-021-03684-z. hdl: 1721.1/142862 . ISSN   1476-4687. PMC   11127244 . PMID   34194041. S2CID   235696393.
  27. Hoffman, Stephen L.; Billingsley, Peter F.; James, Eric; Richman, Adam; Loyevsky, Mark; Li, Tao; Chakravarty, Sumana; Gunasekera, Anusha; Chattopadhyay, Rana; Li, Minglin; Stafford, Richard (January 2010). "Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria". Human Vaccines. 6 (1): 97–106. doi: 10.4161/hv.6.1.10396 . ISSN   1554-8600. PMID   19946222. S2CID   1209024.
  28. Luke, Thomas C.; Hoffman, Stephen L. (November 2003). "Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine". The Journal of Experimental Biology. 206 (Pt 21): 3803–3808. Bibcode:2003JExpB.206.3803L. doi:10.1242/jeb.00644. ISSN   0022-0949. PMID   14506215. S2CID   24138914.
  29. 1 2 3 "Medals -ASTMH" (PDF). ASTMH. Retrieved 2022-02-07.
  30. 1 2 3 4 "Stephen Hoffman | Faculty Member | Faculty Opinions". facultyopinions.com. Retrieved 2022-02-07.
  31. "Member Directory - Asbury Park High School Hall of Fame". www.aphshalloffame.com. Retrieved 2022-02-07.
  32. "Dr. Stephen L. Hoffman wins 2015 CEO of the year at the World Vaccine Congress, Vaccine Industry Excellence Awards – Sanaria" . Retrieved 2022-02-07.
  33. "CORRECTING and REPLACING Tech Council of Maryland Names Winners of 27th Annual Industry Awards". www.businesswire.com. 2015-05-14. Retrieved 2022-02-07.
  34. 1 2 3 "Leadership – Sanaria" . Retrieved 2022-02-03.
  35. "Sanaria's Dr. Stephen L. Hoffman won the Daily Record's Innovator of the Year Award – Sanaria" . Retrieved 2022-03-25.
  36. "ASTMH - Walter Reed Medal". www.astmh.org. Retrieved 2024-11-18.
  37. "Join us in celebrating Stephen L. Hoffman of @Sanaria_Inc for winning the Walter Reed Medal in the field of tropical medicine! #TropMed24". November 14, 2024. Retrieved November 18, 2024.
  38. "ASTMH - Fellows of ASTMH (FASTMH)". www.astmh.org. Retrieved 2022-02-07.
  39. "IDSA Home". www.idsociety.org. Retrieved 2022-03-24.
  40. "The American Society for Clinical Investigation" . Retrieved 2022-02-07.
  41. "Association of American Physicians". aap-online.org. Retrieved 2022-02-07.
  42. "American Academy of Microbiology - Fellow Directory". American Academy of Microbiology. Retrieved 2022-02-07.
  43. "Elected Fellows | American Association for the Advancement of Science". www.aaas.org. Retrieved 2022-02-07.
  44. "ABFM". portfolio.theabfm.org. Retrieved 2022-03-10.
  45. Malaysian, Scientific (2016-06-13). "AMA session with Dr. Betty Kim Lee Sim". Scientific Malaysian Magazine. Retrieved 2022-07-20.
  46. "Alexander Hoffman". linkedin.com.
  47. "Seth Ari Sim-Son Hoffman's Profile | Stanford Profiles". profiles.stanford.edu. Retrieved 2022-07-21.
  48. "Benjamin Hoffman Profile". University of California, San Francisco.