Stephen Oliver (scientist)

Last updated

Steve Oliver
FMedSci
Born
Stephen George Oliver

(1949-11-03) 3 November 1949 (age 75) [1]
Alma mater University of Bristol
Known for
Awards
Scientific career
Institutions
Thesis The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae.  (1975)
Website www.bioc.cam.ac.uk/research/oliver OOjs UI icon edit-ltr-progressive.svg

Stephen George Oliver FMedSci (born 3 November 1949) is an Emeritus Professor in the Department of Biochemistry at the University of Cambridge, [6] [7] and a Fellow of Wolfson College, Cambridge. [3] [8]

Contents

Education

Oliver was educated at the University of Bristol gaining a Bachelor of Science degree in Microbiology in 1971 followed by a PhD from the National Institute for Medical Research (NIMR) in 1974. [9]

Research

Oliver's areas of research include functional genomics, systems biology [10] [11] [12] and drug discovery [13] [14] [15] [16] [17] [18] using the model organism Saccharomyces cerevisiae [19] which he has worked on since the 1970s. [20] In 1992, whilst working at UMIST, Oliver led the team which provided first complete sequence analysis of an entire chromosome from any organism. [21] More recently he has also been involved in the creation of a Robot Scientist [2] [22] and has been awarded research funding as principal investigator or co-investigator with a total value of over £26 million by the Biotechnology and Biological Sciences Research Council (BBSRC). [23]

Related Research Articles

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<span class="mw-page-title-main">Interactome</span> Complete set of molecular interactions in a biological cell

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Robot Scientist is a laboratory robot created and developed by a group of scientists including Ross King, Kenneth Whelan, Ffion Jones, Philip Reiser, Christopher Bryant, Stephen Muggleton, Douglas Kell, Emma Byrne and Steve Oliver.

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References

  1. 1 2 3 Anon (2014). "Oliver, Prof. Stephen George" . Who's Who (online edition via Oxford University Press  ed.). A & C Black. doi:10.1093/ww/9780199540884.013.U247362.(Subscription or UK public library membership required.)
  2. 1 2 King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature. 427 (6971): 247–252. Bibcode:2004Natur.427..247K. doi:10.1038/nature02236. PMID   14724639. S2CID   4428725.
  3. 1 2 "Professor Steve Oliver | Wolfson College Cambridge". Archived from the original on 8 August 2014.
  4. ↑ Cornell, M.; Paton, N. W.; Oliver, S. G. (2004). "A critical and Integrated View of the Yeast Interactome". Comparative and Functional Genomics. 5 (5): 382–402. doi:10.1002/cfg.412. PMC   2447467 . PMID   18629175.
  5. ↑ Oliver, S. (1977). "On the mutability of the yeast mitochondrial genome". Journal of Theoretical Biology. 67 (2): 195–201. Bibcode:1977JThBi..67..195O. doi:10.1016/0022-5193(77)90193-X. PMID   330960.
  6. ↑ Stephen Oliver publications from Europe PubMed Central
  7. ↑ "Steve Oliver – Cambridge Systems Biology Centre". 5 November 2012. Archived from the original on 14 January 2013.
  8. ↑ Stephen Oliver's publications indexed by the Scopus bibliographic database. (subscription required)
  9. ↑ Oliver, Stephen (1975). The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae (PhD thesis). Council for National Academic Awards. ProQuest   301313077.
  10. ↑ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature. 417 (6887): 399–403. Bibcode:2002Natur.417..399V. doi:10.1038/nature750. PMID   12000970. S2CID   4419762.
  11. ↑ Goffeau, A.; Barrell, B. G.; Bussey, H.; Davis, R. W.; Dujon, B.; Feldmann, H.; Galibert, F.; Hoheisel, J. D.; Jacq, C.; Johnston, M.; Louis, E. J.; Mewes, H. W.; Murakami, Y.; Philippsen, P.; Tettelin, H.; Oliver, S. G. (1996). "Life with 6000 Genes". Science. 274 (5287): 546, 563–7. Bibcode:1996Sci...274..546G. doi:10.1126/science.274.5287.546. PMID   8849441. S2CID   16763139.
  12. ↑ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology. 19 (1): 45–50. doi:10.1038/83496. PMID   11135551. S2CID   15491882.
  13. ↑ Kell, D. B.; Dobson, P. D.; Bilsland, E.; Oliver, S. G. (2012). "The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so". Drug Discovery Today. 18 (5–6): 218–39. doi:10.1016/j.drudis.2012.11.008. PMID   23207804.
  14. ↑ Lanthaler, K.; Bilsland, E.; Dobson, P. D.; Moss, H. J.; Pir, P. N.; Kell, D. B.; Oliver, S. G. (2011). "Genome-wide assessment of the carriers involved in the cellular uptake of drugs: A model system in yeast". BMC Biology. 9: 70. doi: 10.1186/1741-7007-9-70 . PMC   3280192 . PMID   22023736.
  15. ↑ Kell, D. B.; Dobson, P. D.; Oliver, S. G. (2011). "Pharmaceutical drug transport: The issues and the implications that it is essentially carrier-mediated only". Drug Discovery Today. 16 (15–16): 704–714. doi:10.1016/j.drudis.2011.05.010. PMID   21624498.
  16. ↑ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology. 4: 145. doi: 10.1186/1752-0509-4-145 . PMC   2988745 . PMID   21029416.
  17. ↑ Dobson, P. D.; Lanthaler, K.; Oliver, S. G.; Kell, D. B. (2009). "Implications of the dominant role of transporters in drug uptake by cells". Current Topics in Medicinal Chemistry. 9 (2): 163–181. doi:10.2174/156802609787521616. PMID   19200003.
  18. ↑ Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.; Pettifer, S.; Simeonidis, E.; Smallbone, K.; Spasić, I.; Weichart, D.; Brent, R.; Broomhead, D. S.; Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.; Palsson, B. Ø.; Sauer, U.; Oliver, S.G.; Mendes, P.; Nielsen, J.; Kell, D.B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology". Nature Biotechnology. 26 (10): 1155–1160. doi:10.1038/nbt1492. PMC   4018421 . PMID   18846089.
  19. ↑ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature. 417 (6887): 399–403. Bibcode:2002Natur.417..399V. doi:10.1038/nature750. PMID   12000970. S2CID   4419762.
  20. ↑ Oliver, S. G.; Williamson, D. H. (1976). "The molecular events involved in the induction of petite yeast mutants by fluorinated pyrimidines". MGG Molecular & General Genetics. 146 (3): 253–259. doi:10.1007/BF00701248. PMID   794690. S2CID   23632777.
  21. ↑ Oliver, S. G.; Van Der Aart, Q. J. M.; Agostoni-Carbone, M. L.; Aigle, M.; Alberghina, L.; Alexandraki, D.; Antoine, G.; Anwar, R.; Ballesta, J. P. G.; Benit, P.; Berben, G.; Bergantino, E.; Biteau, N.; Bolle, P. A.; Bolotin-Fukuhara, M.; Brown, A.; Brown, A. J. P.; Buhler, J. M.; Carcano, C.; Carignani, G.; Cederberg, H.; Chanet, R.; Contreras, R.; Crouzet, M.; Daignan-Fornier, B.; Defoor, E.; Delgado, M.; Demolder, J.; Doira, C.; et al. (1992). "The complete DNA sequence of yeast chromosome III". Nature. 357 (6373): 38–46. Bibcode:1992Natur.357...38O. doi:10.1038/357038a0. PMID   1574125. S2CID   4271784.
  22. ↑ King, P.; Rowland, J.; Aubrey, W.; Liakata, M.; Markham, M.; Soldatova, L. N.; Whelan, K. E.; Clare, A.; Young, M.; Sparkes, A.; Oliver, S. G.; Pir, P. (2009). "The Robot Scientist Adam". Computer. 42 (7): 46–54. doi:10.1109/MC.2009.270. S2CID   13920692.
  23. ↑ "UK Government Grants awarded to Stephen Oliver" . Retrieved 4 July 2014.
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