Douglas Kell

Last updated

Douglas Kell
CBE FRSB FLSW
Douglas Kell (CBE) (cropped).jpg
Douglas Kell at Buckingham Palace after receiving his CBE
Born
Douglas Bruce Kell

(1953-04-07) 7 April 1953 (age 71) [1]
NationalityBritish
Education Bradfield College
Alma mater University of Oxford (BA, DPhil)
Known forCEO of BBSRC
Spouse
Dr Antje Wagner
​
(m. 1989)​
[1]
Children3 [1]
Awards Fellow of the American Association for the Advancement of Science (2012) [2]
Scientific career
Fields
Institutions
Thesis The Bioenergetics of Paracoccus denitrificans  (1978)
Doctoral advisor
  • Stuart Ferguson [4]
  • Philip John
Doctoral students
Website dbkgroup.org OOjs UI icon edit-ltr-progressive.svg


Douglas Bruce Kell CBE FRSB FLSW [6] (born 7 April 1953) [1] is a British biochemist and Professor of Systems Biology in the Institute of Systems, Molecular and Integrative Biology at the University of Liverpool. He was previously at the School of Chemistry at the University of Manchester, based in the Manchester Institute of Biotechnology (MIB) [7] where he founded and led the Manchester Centre for Integrative Systems Biology (MCISB). He served as chief executive officer (CEO) of the Biotechnology and Biological Sciences Research Council (BBSRC) from 2008 to 2013. [8] [9] [10] [11] [12] [13]

Contents

Education and early life

Kell was privately educated at Hydneye House in Sussex [14] and Bradfield College in Berkshire where he was top scholar. He graduated from the University of Oxford with a Bachelor of Arts degree in Biochemistry in 1975 with a distinction in chemical pharmacology, where he was an undergraduate student of St John's College, Oxford. He stayed in Oxford for his Doctor of Philosophy degree, completed in 1978 with a thesis on the bioenergetics of the microbe Paracoccus denitrificans, supervised by Stuart Ferguson [4] [15] and Philip John. [16]

Research and career

From 1978 to 2002 he worked at Aberystwyth University, moving to the University of Manchester Institute of Science and Technology (UMIST) in 2002 as an Engineering and Physical Sciences Research Council (EPSRC) / Royal Society of Chemistry (RSC) Research Chair in Bioanalytical Sciences. (UMIST merged with the Victoria University of Manchester in 2004, to become the University of Manchester.) He moved to the University of Liverpool in 2018 to work in the Johnston Laboratories, which were the world's first department of biochemistry at a University.[ citation needed ]

Kell's primary research interests are in systems biology, synthetic biology and computational biology. [3] He has also been involved in the development of multivariate scientific instrumentation and the attendant machine learning software (his first paper on artificial neural networks was in 1992). He has written extensively on the role of microbes as agents of supposedly 'non-communicable', chronic infectious diseases. His publications are mostly open access and are very widely cited, with an H-index at Google Scholar in excess of 130. According to Google Scholar [3] his most cited peer-reviewed research papers are in functional genomics, [17] metabolomics [18] and the yeast genome. [19] He has also been involved in research to create a robot scientist [20] in collaboration with Ross King, Stephen Muggleton and Steve Oliver, as well as several projects in systems biology. [21] [22] [23] [24] [25] He is involved in the study of membrane transporters, and their necessary involvement in the transmembrane uptake of pharmaceutical drugs. [26] He tends to choose scientific problems in which the prevailing orthodoxy is clearly incorrect. To this end, he has recently returned to the study of bioenergetics, summarising the detailed evidence against the prevailing wisdom of chemiosmotic coupling in oxidative and photosynthetic phosphorylation, replacing it with a protet-based model. [27] [28]

With his collaborator Resia Pretorius, Kell discovered the amyloidogenic clotting of blood, involving the amyloidogenic self-assembly of the clotting protein fibrin into highly stable β-sheets that — unlike regular clots — are resistant to plasmin, the enzyme responsible for breaking up clots (fibrinolysis). [29] They report that such amyloidogenic clotting appears to be mostly caused by infectious agents, even in supposedly non-infectious diseases. [30] Kell and Pretorius report that such fibrin amyloid microclots (fibrinaloids) seem to be of major significance in long COVID. [31]

In 1988, he was a founding director of Aber Instruments, based at Aberystwyth Science Park (originally at the Centre for Alternative Technology (CAT), Machynlleth, Wales). In 2019 he was a co-founding director of Mellizyme Ltd, now Epoch Biodesign [32]  ; he left the company in 2023. He cofounded PhenUTest Ltd in 2021. He is an Associated Scientific Director of the Centre for Biosustainability at the Technical University of Denmark, where he runs the Flux Optimisation and Bioanalytics Group.

Kell's research has been funded by the European Union (EU), the BBSRC, the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council (EPSRC). [33] [34] His former doctoral students and postdoctoral researchers include Pedro Mendes. [5] His monograph Belief: the baggage behind our being was published in 2018. [35] [36]

Awards and honours

Kell was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours, for services to science and research. [6] Kell is also a Fellow of the Learned Society of Wales (FLSW), a Fellow of the Royal Society of Biology (FRSB) and a Fellow of the American Association for the Advancement of Science (FAAS). [2]

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References

  1. 1 2 3 4 Anon (2024). "Kell, Prof. Douglas Bruce" . Who's Who (176th ed.). Oxford: Oxford University Press. p. 2736. doi:10.1093/ww/9780199540884.013.42346. ISBN   9781399409452. OCLC   1402257203.(Subscription or UK public library membership required.)
  2. 1 2 "AAAS - 2012 Fellows". Archived from the original on 23 March 2013.
  3. 1 2 3 Douglas Kell publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  4. 1 2 Kell, D.; John, P.; Ferguson, S. (1978). "The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans. Magnitude, sites of generation and comparison with the phosphorylation potential". The Biochemical Journal . 174 (1): 257–266. doi:10.1042/bj1740257. PMC   1185905 . PMID   212022.
  5. 1 2 Mendes, Pedro Pedrosa (1994). Computer simulation of the dynamics of biochemical pathways (PhD thesis). University of Aberystwyth. Archived from the original on 14 April 2013. Retrieved 18 June 2012.
  6. 1 2 "No. 60728". The London Gazette (Supplement). 31 December 2013. p. 9.
  7. ↑ Kell, Douglas (2012). "Prof Douglas Kell, research profile - personal details". University of Manchester. Archived from the original on 14 March 2012. Retrieved 12 June 2012.
  8. ↑ "19 June 2012 - Reappointment of Chief Executive for the Biotechnology and Biological Sciences Research Council - News - BBSRC". Archived from the original on 26 June 2012.
  9. ↑ Van Noorden, Richard (24 November 2008). "Interview: Douglas Kell". Chemistry World. Retrieved 7 June 2017.
  10. ↑ Interview with Douglas Kell on the website of the Royal Society of Chemistry
  11. ↑ Douglas Kell author profile page at the ACM Digital Library
  12. ↑ Douglas Kell publications from Europe PubMed Central
  13. ↑ Kell, D. B.; Lurie-Luke, E (2015). "The virtue of innovation: Innovation through the lenses of biological evolution". Journal of the Royal Society Interface. 12 (103): 20141183. doi:10.1098/rsif.2014.1183. PMC   4305420 . PMID   25505138.
  14. ↑ "Hydneye House - a set on Flickr". Archived from the original on 23 January 2013. Retrieved 18 January 2017.
  15. ↑ "Prof Stuart Ferguson Page - Department of Biochemistry, University of Oxford". Archived from the original on 20 May 2013.
  16. ↑ Kell, Douglas Bruce (1978). The bioenergetics of paracoccus denitrificans. ora.ox.ac.uk (DPhil thesis). University of Oxford. OCLC   863351446. EThOS   uk.bl.ethos.461649. Lock-green.svg
  17. ↑ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology. 19 (1): 45–50. doi:10.1038/83496. PMID   11135551. S2CID   15491882.
  18. ↑ Goodacre, R.; Vaidyanathan, S.; Dunn, W. B.; Harrigan, G. G.; Kell, D. B. (2004). "Metabolomics by numbers: Acquiring and understanding global metabolite data". Trends in Biotechnology. 22 (5): 245–252. doi:10.1016/j.tibtech.2004.03.007. PMID   15109811.
  19. ↑ Oliver, S.; Winson, M.; Kell, D.; Baganz, F. (1998). "Systematic functional analysis of the yeast genome". Trends in Biotechnology. 16 (9): 373–378. CiteSeerX   10.1.1.33.5221 . doi:10.1016/S0167-7799(98)01214-1. PMID   9744112.
  20. ↑ King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature . 427 (6971): 247–252. Bibcode:2004Natur.427..247K. doi:10.1038/nature02236. PMID   14724639. S2CID   4428725. Closed Access logo transparent.svg
  21. ↑ Kell, Douglas (2009). "Journal club: A systems biologist ponders how disparate ideas can sometimes come together beautifully". Nature. 460 (7256): 669. Bibcode:2009Natur.460..669K. doi: 10.1038/460669e . PMID   19661875. S2CID   1857476.
  22. ↑ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology. 4: 145. doi: 10.1186/1752-0509-4-145 . PMC   2988745 . PMID   21029416.
  23. ↑ Pir, P.; Gutteridge, A.; Wu, J.; Rash, B.; Kell, D. B.; Zhang, N.; Oliver, S. G. (2012). "The genetic control of growth rate: A systems biology study in yeast". BMC Systems Biology. 6: 4. doi: 10.1186/1752-0509-6-4 . PMC   3398284 . PMID   22244311.
  24. ↑ Douglas B. Kell at DBLP Bibliography Server OOjs UI icon edit-ltr-progressive.svg
  25. ↑ Douglas Kell's publications indexed by the Scopus bibliographic database. (subscription required)
  26. ↑ "How Drugs Really Get Into Cells: Why Passive Bilayer Diffusion is a Myth". 30 April 2020. Archived from the original on 15 April 2021.
  27. ↑ Kell, Douglas Bruce (9 February 2020). "Protet_PCT model of ETP".
  28. ↑ Kell, Douglas B. (2021). "A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation". Advances in Microbial Physiology. Vol. 78. Elsevier. pp. 1–177. doi:10.1016/bs.ampbs.2021.01.001. ISBN   9780128246016. ISSN   0065-2911. PMID   34147184. S2CID   234894761.
  29. ↑ Pretorius E, Mbotwe S, Bester J, Robinson CJ, Kell DB (September 2016). "Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide". J R Soc Interface. 13 (122): 20160539. doi:10.1098/rsif.2016.0539. PMC   5046953 . PMID   27605168.
  30. ↑ Kell, Douglas B.; Pretorius, Etheresia (2017). "Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting". Prog. Biophys. Mol. Biol. 123: 6–41. doi:10.1016/j.pbiomolbio.2016.08.006. hdl: 2263/59001 . PMID   27554450.
  31. ↑ Kell, Douglas B.; Laubscher, Gert Jacobus; Pretorius, Etheresia (23 February 2022). "A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications". Biochemical Journal. 479 (4): 537–559. doi:10.1042/BCJ20220016. eISSN   1470-8728. ISSN   0264-6021. PMC   8883497 . PMID   35195253.
  32. ↑ "Epoch BioDesign". epochbiodesign.com.
  33. ↑ UK Government Grants awarded to Douglas Kell, via Research Councils UK
  34. ↑ Grants awarded to Douglas Kell by the Engineering and Physical Sciences Research Council
  35. ↑ Kell, Doug (15 March 2018). "We have written a free book (monograph) on why people believe crazy things, including #Brexit ". Twitter @dbkell. Retrieved 19 March 2018.
  36. ↑ Kell DB, Welch GR (2018) Belief: the baggage behind our being. OSF preprints doi : 10.17605/OSF.IO/PNXCS Open Access logo PLoS transparent.svg
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