The Manchester Institute of Biotechnology, formerly the Manchester Interdisciplinary Biocentre (MIB) is a research institute of the University of Manchester, England.
The centre has been designed to enable academic communities to explore specific areas of interdisciplinary quantitative bioscience, largely through the efforts of multidisciplinary research teams. Research at MIB follows three broadly defined, interdisciplinary and complementary themes: Biological Mechanism and Catalysis, Molecular Bioengineering, and Systems biology. [1] [2] [3] [4]
Planning for the institute began late in 1998 and culminated with the official opening on 25 October 2006 of the John Garside Building. The building won "Building of the Year" from Manchester Chamber's Building and Development Committee in 2006 along with Beetham Tower, Manchester.[ citation needed ]
The building has featured in several television commercials, notably Injury Lawyers 4u. [5]
The institute was renamed the Manchester Institute of Biotechnology on 1 June 2012, retaining the acronym MIB. [6]
In November 2019 the MIB was awarded the Queen’s Anniversary Prize for Higher and Further Education. The award is a recognition of the MIB as a 'beacon of excellence' for work in Industrial Biotechnology.
Modelling biological systems is a significant task of systems biology and mathematical biology. Computational systems biology aims to develop and use efficient algorithms, data structures, visualization and communication tools with the goal of computer modelling of biological systems. It involves the use of computer simulations of biological systems, including cellular subsystems, to both analyze and visualize the complex connections of these cellular processes.
Vitamin K epoxide reductase (VKOR) is an enzyme that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid residues in blood coagulation enzymes. VKOR is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea. In some plant and bacterial homologues, the VKOR domain is fused with domains of the thioredoxin family of oxidoreductases.
Rudolf Aebersold is a Swiss biologist, regarded as a pioneer in the fields of proteomics and systems biology. He has primarily researched techniques for measuring proteins in complex samples, in many cases via mass spectrometry. Ruedi Aebersold is a professor of Systems biology at the Institute of Molecular Systems Biology (IMSB) in ETH Zurich. He was one of the founders of the Institute for Systems Biology in Seattle, Washington, where he previously had a research group.
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. A nuclear protein present in most eukaryotes and highly conserved across species, numerous functions have been elucidated for geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. One example of its function is the inhibition of Cdt1.
Dame Janet Maureen Thornton, is a senior scientist and director emeritus at the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL). She is one of the world's leading researchers in structural bioinformatics, using computational methods to understand protein structure and function. She served as director of the EBI from October 2001 to June 2015, and played a key role in ELIXIR.
Proteasome inhibitor PI31 subunit is a protein that in humans is encoded by the PSMF1 gene.
Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene.
The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.
Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.
ATP synthase subunit delta, mitochondrial, also known as ATP synthase F1 subunit delta or F-ATPase delta subunit is an enzyme that in humans is encoded by the ATP5F1D gene. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation.
Douglas Bruce Kell is a British biochemist and Research Professor of Systems Biology in the Institute of Systems, Molecular and Integrative Biology at the University of Liverpool, and Chief Scientific Officer of Epoch Biodesign Ltd. He was previously at the School of Chemistry at the University of Manchester, based in the Manchester Institute of Biotechnology (MIB). He founded and led the Manchester Centre for Integrative Systems Biology. He served as chief executive officer (CEO) of the Biotechnology and Biological Sciences Research Council (BBSRC) from 2008 to 2013.
Matthew P. Scott is an American biologist who was the tenth president of the Carnegie Institution for Science. While at Stanford University, Scott studied how embryonic and later development is governed by proteins that control gene activity and cell signaling processes. He co- discovered homeobox genes in Drosophila melanogaster working with Amy J. Weiner at Indiana University.
The Institute of Molecular Biotechnology (IMBA) is an independent biomedical research organisation founded by the Austrian Academy of Sciences in cooperation with the pharmaceutical company Boehringer Ingelheim. The institute employs around 220 people from over 40 countries, who perform basic research. The IMBA operates in close collaboration with the Research Institute of Molecular Pathology (IMP), the basic research center of Boehringer Ingelheim. Both institutes are located next to each other at the Vienna Biocenter (VBC).
Laurence Harris Pearl FRS FMedSci is a British biochemist and structural biologist who is currently Professor of Structural Biology in the Genome Damage and Stability Centre and was Head of the School of Life Sciences at the University of Sussex.
Nigel Shaun Scrutton is a British biochemist and biotechnology innovator known for his work on enzyme catalysis, biophysics and synthetic biology. He is Director of the UK Future Biomanufacturing Research Hub, Director of the Fine and Speciality Chemicals Synthetic Biology Research Centre (SYNBIOCHEM), and Co-founder, Director and Chief Scientific Officer of the 'fuels-from-biology' company C3 Biotechnologies Ltd. He is Professor of Enzymology and Biophysical Chemistry in the Department of Chemistry at the University of Manchester. He is former Director of the Manchester Institute of Biotechnology (MIB).
Narayanaswamy Srinivasan was an Indian molecular biophysicist and a professor and the head of Proteins: Structure, Function and Evolutionary Group at the Molecular Biophysics Unit of the Indian Institute of Science. He is known for his researches in the fields of computational genomics and protein structure analysis. An elected fellow of the Indian Academy of Sciences and the National Academy of Sciences, India, he is a J. C. Bose National fellow of the Department of Biotechnology and a recipient of the National Bioscience Award for Career Development of the Department of Science and Technology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2007, for his contributions to biological sciences.
Balasubramanian Gopal is an Indian structural biologist, molecular biophysicist and a professor at the Molecular Biophysics Unit of the Indian Institute of Science. He is known for his studies on cell wall synthesis in Staphylococcus aureus and is an elected fellow of the National Academy of Sciences, India, Indian National Science Academy and the Indian Academy of Sciences. He received the National Bioscience Award for Career Development of the Department of Biotechnology in 2010. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2015, for his contributions to biological sciences.
Sagar Sengupta is an Indian immunologist, cancer biologist and a scientist at the National Institute of Immunology, India. Known for his studies on tumor suppressor gene and oncogenes, Sengupta is an elected fellow of all the three major Indian science academies namely the National Academy of Sciences, India, the Indian National Science Academy and the Indian Academy of Sciences. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2011.
Patrick D'Silva is an Indian cell biologist, biochemist, and an associate professor at the Molecular Chaperone Lab of the Indian Institute of Science. He is known for his medical discoveries related to neurodegenerative diseases and cancer biology. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2014.
Sabine Flitsch is a German organic chemist and chemical biologist who holds a personal chair in Chemical Biology at the University of Manchester School of Chemistry, where she runs an active research glycobiology research group based in the Manchester Interdisciplinary Biocentre.
Coordinates: 53°28′23″N2°14′08″W / 53.47306°N 2.23556°W