Streptomyces is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin.
Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
Streptomyces spectabilis is a bacterium species from the genus of Streptomyces. Streptomyces spectabilis produces hangtaimycin, gentamicin, kanamycin, neomycin B, sisomycin, tobramycin, paromomycin, spectinabilin, spectinomycin, aminocyclitol, actinospectacin, prodigiosine and the streptovaricin complex.
Ribostamycin is an aminoglycoside-aminocyclitol antibiotic isolated from a streptomycete, Streptomyces ribosidificus, originally identified in a soil sample from Tsu City of Mie Prefecture in Japan. It is made up of 3 ring subunits: 2-deoxystreptamine (DOS), neosamine C, and ribose. Ribostamycin, along with other aminoglycosides with the DOS subunit, is an important broad-spectrum antibiotic with important use against human immunodeficiency virus and is considered a critically important antimicrobial by the World Health Organization., Resistance against aminoglycoside antibiotics, such as ribostamycin, is a growing concern. The resistant bacteria contain enzymes that modify the structure through phosphorylation, adenylation, and acetylation and prevent the antibiotic from being able to interact with the bacterial ribosomal RNAs.
Naphthomycins are a group of closely related antimicrobial chemical compounds isolated from Streptomyces. They are considered a subclass of ansamycins.
The Center for Pharmaceutical Research and Innovation (CPRI) is a University of Kentucky-based research center established by the University of Kentucky College of Pharmacy in 2012 to facilitate academic translational research and drug discovery/drug development. The UK CPRI specializes in natural product-based drug discovery from microbes found within unique environments including underground and surface coal mines, acid mine drainage and mine reclamation sites, thermal vents associated with underground coal mine fires and deep-well drilling for carbon sequestration. CPRI also provides core support for medicinal chemistry, assay development and screening, rational drug design, computational chemistry, and ADMET. The Center collaborates with investigators focused on drug discovery or development research in the areas of cancer, drug and alcohol addiction, cardiovascular disease, infectious disease, regenerative medicine and neurodegenerative disease.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of Actinomycetota, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium.
Streptomyces albidoflavus is a bacterium species from the genus of Streptomyces which has been isolated from soil from Poland. Streptomyces albidoflavus produces dibutyl phthalate and streptothricins.
Streptomyces aurantiogriseus is a bacterium species from the genus Streptomyces which has isolated from soil in Russia. Streptomyces aurantiogriseus produces differolide and acetamidobenzoic acid.
Streptomyces chartreusis is a bacterium species from the genus of Streptomyces which has been isolated from soil in Africa. Streptomyces chartreusis produces N-deacyltunicamycin, elsamicin A, aminoacylase and chartreusin.
Streptomyces corchorusii is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces corchorusii produces butalactin.
Streptomyces diastaticus is an alkaliphilic and thermophilic bacterium species from the genus of Streptomyces. Streptomyces diastaticus produces oligomycin A, oligomycin C, rimocidin and the leukotriene-A4 hydrolase-inhibitor 8(S)-amino-2(R)-methyl-7-oxononanoic acid. Streptomyces diastaticus also produces gougerotin and diastaphenazine and the antibiotic ruticin.
Streptomyces diastatochromogenes is a bacterium species from the genus of Streptomyces. Streptomyces diastatochromogenes produces polyketomycin, concanamycin A, concanamycin B, concanamycin C, momofulvenone A, azdimycin, toyocamycin and oligomycins.
Streptomyces halstedii is a bacterium species from the genus of Streptomyces which has been isolated from deeper soil layers. Streptomyces halstedii produces magnamycin B, vicenistatin deltamycin A2, deltamycin A3, bafilomycin B1 and bafilomycin C1. Streptomyces halstedii also produces complex antifungal antibiotics like oligomycins and the antibiotics anisomycin and sinefungin.
Streptomyces litmocidini is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces litmocidini produces granaticin and litmocidin.
Streptomyces longispororuber is a bacterium species from the genus of Streptomyces. Streptomyces longispororuber produces corallomycin.
Streptomyces phaeofaciens is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces phaeofaciens produces phaeofacin.
Streptomyces recifensis is a bacterium species from the genus of Streptomyces which has been isolated from soil from Recife in Brazil.
Streptomyces variegatus is a bacterium species from the genus of Streptomyces. Streptomyces variegatus produces prodigiosin.
Streptomyces virens is a bacterium species from the genus of Streptomyces. Streptomyces virens produces virenomycin.
