Streptomyces iakyrus

Last updated

Streptomyces iakyrus
Scientific classification
Kingdom:
Phylum:
Class:
Order:
Family:
Genus:
Species:
S. iakyrus
Binomial name
Streptomyces iakyrus
de Querioz and Albert 1962 [1]
Type strain
ATCC 15375, BCRC 11930, CBS 702.72, CCRC 11930, CGMCC 4.1912, DSM 40482, IAUR 3119, IAUR 3923, IFO 13401, INMI 15375, ISP 5482, JCM 4254, JCM 4773, KCC S-0254, NBRC 13401, NRRL B-3317, NRRL B-3634, NRRL B-B-3634, NRRL-ISP 5482, RIA 1362, VKM Ac-201 [2]

Streptomyces iakyrus is a bacterium species from the genus of Streptomyces which has been isolated from soil [1] [3] [4] Streptomyces iakyrus produces actinomycin G2, actinomycin G3, actinomycin G4, actinomycin G5, actinomycin G6, iakirine I, iakirine II and iakirine III. [4] [5] [6]

Contents

See also

Related Research Articles

<i>Streptomyces</i>

Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described. As with the other Actinobacteria, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin.

Clavulanic acid

Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.

Novobiocin

Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides a member of the order Actinobacteria. Other aminocoumarin antibiotics include clorobiocin and coumermycin A1. Novobiocin was first reported in the mid-1950s.

Plicamycin

Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor. The manufacturer discontinued production in 2000. Several different structures are currently reported in different places all with the same chromomycin core, but with different stereochemistry in the glycoside chain, a 1999 study has re-investigated the compound and proposed a revised structure.

CCR3 (gene)

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.

The aminocyclitols are compounds related to cyclitols. They possess features of relative and absolute configuration that are characteristic of their class and have been extensively studied; but these features are not clearly displayed by general methods of stereochemical nomenclature, so that special methods of specifying their configuration are justified and have long been used. In other than stereochemical respects, their nomenclature should follow the general rules of organic chemistry.

Procyanidin A1

Procyanidin A1 is an A type proanthocyanidin dimer.

Cucurbitane

Cucurbitane is a class of chemical compounds with formula C
30
H
54
. There are a polycyclic hydrocarbon, specifically triterpene. There are isomers of lanostane, from which it differs by the formal shift of a methyl group from the 10 to the 9β position in the standard steroid numbering scheme.

In molecular biology mir-367 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Plantazolicin (PZN) is a natural antibiotic produced by the gram-positive soil bacterium Bacillus velezensis FZB42. PZN has specifically been identified as a selective bactericidal agent active against Bacillus anthracis, the causative agent of anthrax. This natural product is a ribosomally synthesized and post-translationally modified peptide (RiPP); it can be classified further as a thiazole/oxazole-modified microcin (TOMM) or a linear azole-containing peptide (LAP).

Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of actinobacteria, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium.

Cyclothiazomycin

The cyclothiazomycins are a group of natural products, classified as thiopeptides, which are produced by various Streptomyces species of bacteria.

Nosiheptide

Nosiheptide is a thiopeptide antibiotic produced by the bacterium Streptomyces actuosus.

Streptomyces antibioticus is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus' chain-like spore production, and "antibioticus", referring to this species' extensive antibiotic production. Upon its first characterization, it was noted that S. antibioticus produces a distinct soil odor.

Streptomyces collinus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Baden in Germany. Streptomyces collinus produces ansatrienin A2, ansatrienin A3, ansatrienin B, naphthomycin A, collinomycine, toromycin, streptocollin, kirromycin and rubromycine.

Streptomyces flavoviridis is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces flavoviridis produces phleomycin and zorbamycin.

Streptomyces griseoviridis is a filamentous bacterium species from the genus of Streptomyces which has been isolated from soil in Texas in the United States. Streptomyces griseoviridis produces etamycin, griseoviridin, bactobolin, prodigiosin R1 and rosophilin. Streptomyces griseoviridis inhibits the growth of fungal pathogens and can be used to protect plants from those.

Streptomyces leeuwenhoekii is a bacterium species from the genus of Streptomyces which has been isolated from hyper-arid desert soil from Salar de Atacama in Chile. Streptomyces leeuwenhoekii produces chaxalactins and chaxamycins.

Streptomyces regensis is a bacterium species from the genus of Streptomyces. Streptomyces regensis produces actinomycin and cyanohydrin phosphonate.

Fostriecin is a type I polyketide synthase (PKS) derived natural product, originally isolated from the soil bacterium Streptomyces pulveraceus. It belongs to a class of natural products which characteristically contain a phosphate ester, an α,β-unsaturated lactam and a conjugated linear diene or triene chain produced by Streptomyces. This class includes structurally related compounds cytostatin and phoslactomycin. Fostriecin is a known potent and selective inhibitor of protein serine/threonine phosphatases, as well as DNA topoisomerase II. Due to its activity against protein phosphatases PP2A and PP4 which play a vital role in cell growth, cell division, and signal transduction, fostriecin was looked into for its antitumor activity in vivo and showed in vitro activity against leukemia, lung cancer, breast cancer, and ovarian cancer. This activity is thought to be due to PP2A's assumed role in regulating apoptosis of cells by activating cytotoxic T-lymphocytes and natural killer cells involved in tumor surveillance, along with human immunodeficiency virus-1 (HIV-1) transcription and replication.

References

  1. 1 2 LPSN bacterio.net
  2. Straininfo of Streptomyces iakyrus
  3. UniProt
  4. 1 2 Deutsche Sammlung von Mikroorganismen und Zellkulturen
  5. ATCC
  6. Bitzer, Jens; Gesheva, Victoria; Zeeck, Axel (August 2006). "Actinomycins with Altered Threonine Units in the β-Peptidolactone". Journal of Natural Products. 69 (8): 1153–1157. doi:10.1021/np060063g. PMID   16933866.

Further reading