Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus.
Streptomyces cacaoi is a bacterium species from the genus of Streptomyces. Streptomyces cacaoi produces polyoxine.
Streptomyces calvus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Dinepur in India. Streptomyces calvus produces nucleocidin, adiposin 1 and adiposin 2.
Streptomyces chromofuscus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces chromofuscus produces phospholipase D, herboxidiene, pentalenolactone O and carazostatins.
Streptomyces cinnamoneus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces cinnamoneus produces duramycin A, duramycin B, duramycin C, carbomycin, cinnomycin and fungichromin.
Streptomyces filamentosus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces filamentosus produces caryomycin. Streptomyces filamentosus also produces the novel cyclic lipopeptide antibiotic daptomycin.
Streptomyces griseoviridis is a filamentous bacterium species from the genus Streptomyces, which was isolated from soil in Texas, United States. Streptomyces griseoviridis produces etamycin, griseoviridin, bactobolin, prodigiosin R1, actinobolin, and rosophilin. Streptomyces griseoviridis can be used to protect plants since it inhibits the growth of fungal pathogens.
Streptomyces halstedii is a bacterium species from the genus of Streptomyces which has been isolated from deeper soil layers. Streptomyces halstedii produces magnamycin B, vicenistatin deltamycin A2, deltamycin A3, bafilomycin B1 and bafilomycin C1. Streptomyces halstedii also produces complex antifungal antibiotics like oligomycins and the antibiotics anisomycin and sinefungin.
Streptomyces lusitanus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces lusitanus produces 7-chlortetracycline, naphthyridinomycin, cyanocycline B, N-desmethylnaphthyridinomycin and tetracycline.
Streptomyces nitrosporeus is a bacterium species from the genus of Streptomyces which has been isolated from garden soil in Japan. Streptomyces nitrosporeus produces Benzastatin E, Benzastatin F, Benzastatin G Nitrosporeusine A and Nitrosporeusine B and the antibiotics nitrosporin and virantomycin and the inhibitor of angiotensin-converting enzyme foroxymithine. Streptomyces nitrosporeus can degrade cellulose.
Streptomyces nogalater is a bacterium species from the genus of Streptomyces. Streptomyces nogalater produces nogalamycin.
Streptomyces olivaceus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces olivaceus produces granaticin, elloramycin, tetroazolemycin A and tetroazolemycin B. Streptomyces olivaceus can be used to produce vitamin B12.
Streptomyces platensis is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces platensis produces oxytetracycline, platensimycin, migrastatin, isomigrastatin, platencin, dorrigocin A, dorrigocin B and terramycine.
Streptomyces rishiriensis is a bacterium species from the genus of Streptomyces which has been isolated from soil in Hokkaido in Japan. Streptomyces rishiriensis produces coumermycin A1, notomycin, 2-chloroadenosine, phosphophenylalanarginine and lactonamycin.
Streptomyces roseofulvus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces roseofulvus produces deoxyfrenolicin and frenolicin B.
Streptomyces sanglieri is a bacterium species from the genus of Streptomyces which has been isolated from soil from a hay meadow. Streptomyces sanglieri produces the antibiotic lactonamycin Z.
Streptomyces spiroverticillatus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces spiroverticillatus produces tautomycin.
Streptomyces violaceoruber is a bacterium species from the genus of Streptomyces. Streptomyces violaceoruber produces protoactinorhodin, kendomycin, phospholipase A2, granaticin and methylenomycin A.
Streptomyces virginiae is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces virginiae produces actithiazic acid, virginiamycins and cycloserine. Streptomyces virginiae also produces monensin A, monensin B, monensin C, monensin D, actithiazic acid.
Fostriecin is a type I polyketide synthase (PKS) derived natural product, originally isolated from the soil bacterium Streptomyces pulveraceus. It belongs to a class of natural products which characteristically contain a phosphate ester, an α,β-unsaturated lactam and a conjugated linear diene or triene chain produced by Streptomyces. This class includes structurally related compounds cytostatin and phoslactomycin. Fostriecin is a known potent and selective inhibitor of protein serine/threonine phosphatases, as well as DNA topoisomerase II. Due to its activity against protein phosphatases PP2A and PP4 which play a vital role in cell growth, cell division, and signal transduction, fostriecin was looked into for its antitumor activity in vivo and showed in vitro activity against leukemia, lung cancer, breast cancer, and ovarian cancer. This activity is thought to be due to PP2A's assumed role in regulating apoptosis of cells by activating cytotoxic T-lymphocytes and natural killer cells involved in tumor surveillance, along with human immunodeficiency virus-1 (HIV-1) transcription and replication.
