Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. Over 700 species of Streptomyces bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have very large genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Different strains of the same species may colonize very diverse environments.
The Actinomycetales is an order of Actinomycetota. A member of the order is often called an actinomycete. Actinomycetales are generally gram-positive and anaerobic and have mycelia in a filamentous and branching growth pattern. Some actinomycetes can form rod- or coccoid-shaped forms, while others can form spores on aerial hyphae. Actinomycetales bacteria can be infected by bacteriophages, which are called actinophages. Actinomycetales can range from harmless bacteria to pathogens with resistance to antibiotics.
Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer. This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ovarian cancer. It is given by injection into a vein.
Streptomyces scabiei is a streptomycete bacterium species found in soils around the world. Unlike most of the 500 or so Streptomyces species it is a plant pathogen causing corky lesions to form on tuber and root crops as well as decreasing the growth of seedlings. Along with other closely related species it causes the potato disease common scab, which is an economically important disease in many potato growing areas. It was first described in 1892, being classified as a fungus, before being renamed in 1914 and again in 1948. Several other species of Streptomyces cause similar diseases to S. scabiei but other, more closely related species, do not.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of Actinomycetota, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium.
Streptomyces antibioticus is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus' chain-like spore production, and "antibioticus", referring to this species' extensive antibiotic production. Upon its first characterization, it was noted that S. antibioticus produces a distinct soil odor.
Streptomyces anandii is a bacterium species from the genus Streptomyces which has been isolated from soil from in the region of Al-Taif in Saudi Arabia. Streptomyces anandii produces pentaene G8, gilvocarcin V, gilvocarcin M and gilvocarcin E.
Streptomyces anulatus is a bacterium species from the genus Streptomyces which has been isolated from soil. Streptomyces anulatus produces cactinomycin, endophenazine A, endophenazine B, tubermycin B, endophenazine C, epocarbazolin A, epocarbazolin B, dextranase, telomestatin and actinomycin C.
Streptomyces cuspidosporus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Kyoto in Japan. Streptomyces cuspidosporus produces xylanase, sparsomycin and tubercidin.
Streptomyces flaveolus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces flaveolus produces L-isoleucine, actinomycin J and tirandamycin.
Streptomyces flavovirens is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces flavovirens produces the actinomycin complex and mureidomycin. A strain of this species has been used to produce pravastatin.
Streptomyces galbus is a bacterium species from the genus of Streptomyces which has been isolated from soil from West Bengal. Streptomyces galbus produces xylanase, galbonolides A, galbonolides B and the actinomycin X complex.
Streptomyces griseoruber is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces griseoruber produces beromycin, actinomycin D, gombapyrone A, gombapyrone B, gombapyrone C, gombapyrone D and rhodomycins
Streptomyces iakyrus is a bacterium species from the genus of Streptomyces which has been isolated from soil Streptomyces iakyrus produces actinomycin G2, actinomycin G3, actinomycin G4, actinomycin G5, actinomycin G6, iakirine I, iakirine II and iakirine III.
Streptomyces michiganensis is a bacterium species from the genus of Streptomyces which has been isolated from soil in the United States. Streptomyces michiganensis produces actinomycin X, antipain and mitomycin.
Streptomyces murinus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces murinus produces the actinomycin X complex and glucose isomerase Streptomyces murinus can be used for its production of glucose isomerase in the food industry. Streptomyces murinus produces lankamycin and lankacidin.
Streptomyces parvulus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces parvulus produces the peptide antibiotic Actinomycin D and the angiogenesis inhibitor borrelidin and manumycin A, himalomycin A, himalomycin B and kynurenine.
Streptomyces parvus is a bacterium species from the genus of Streptomyces which has been isolated from garden soil. Streptomyces parvus produces the actinomycin C complex, arylomycin A5, arylomycin A6 and actinomycin D.
Streptomyces rochei is a bacterium species from the genus of Streptomyces which has been isolated from soil in Russia. Streptomyces rochei produces borrelidin, butyrolactol A, butyrolactol B, uricase and streptothricin. Streptomyces rochei has antifungal activity against Fusarium oxysporum f.sp. lycopersici and Aspergillus fumigatus. Streptomyces rochei produces moenomycin and bambermycin. Streptomyces rochei produces amicetin A, amicetin B, amicetin C and streptolin. Streptomyces rochei produces endo-β-N-acetylglucosaminidase mithramycin, amicetin, bamicetin, and plicacetin.
Streptomyces somaliensis is a proteolytic bacterium species from the genus of Streptomyces which has been isolated from a mycetoma from the foot of a man in Somalia. Streptomyces somaliensis is a human pathogen and can cause actinomycosis.
