TAF1D

TAF1D
Identifiers
Aliases	TAF1D , JOSD3, RAFI41, TAF(I)41, TAFI41, TATA-box binding protein associated factor, RNA polymerase I subunit D
External IDs	OMIM: 612823 MGI: 1922566 HomoloGene: 11472 GeneCards: TAF1D
Gene location (Human)
Chr.	Chromosome 11 (human)
End	93,784,391 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	15,316,991 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; visceral pleura; ; sural nerve; ; parietal pleura; ; pylorus; ; Brodmann area 23; ; right uterine tube; ; gastric mucosa; ; tibia; ; Achilles tendon;
	Top expressed in
	superior surface of tongue; ; morula; ; ectoderm; ; otic placode; ; yolk sac; ; blastocyst; ; saccule; ; spermatocyte; ; thymus; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; protein binding ;
Cellular component	RNA polymerase transcription factor SL1 complex ; nucleus ; nucleoplasm ; microtubule organizing center ;
Biological process	transcription initiation from RNA polymerase I promoter ; termination of RNA polymerase I transcription ; epigenetic maintenance of chromatin in transcription-competent conformation ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; transcription elongation from RNA polymerase I promoter ;
	Sources:Amigo / QuickGO
Orthologs
	79101
	75316
	ENSG00000166012
	ENSMUSG00000031939
	Q9H5J8
	Q9D4V4
	NM_024116
	NM_026541 ; NM_027261 ; NM_029248
	NP_077021
	NP_081537 ; NP_083524
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa is a protein that in humans is encoded by the TAF1D gene.^[5]

Function

TAF1D is a member of the SL1 complex, which includes TBP and TAF1A, TAF1B, and TAF1C, and plays a role in RNA polymerase I transcription.^[6]^[7]

Related Research Articles

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Transcription factor II D (TF_IID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins. Before the start of transcription, the transcription Factor II D (TF_IID) complex binds to the core promoter DNA of the gene through specific recognition of promoter sequence motifs, including the TATA box, Initiator, Downstream Promoter, Motif Ten, or Downstream Regulatory elements.

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 gene.

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.

Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.

snRNA-activating protein complex subunit 3 is a protein that in humans is encoded by the SNAPC3 gene.

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene.

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166012 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031939 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa".
↑ Wang L, Bhattacharyya N, Chelsea DM, Escobar PF, Banerjee S (November 2004). "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype". Cancer Research. 64 (21): 7673–7. doi: 10.1158/0008-5472.CAN-04-2801 . PMID 15520167.
↑ Gorski JJ, Pathak S, Panov K, Kasciukovic T, Panova T, Russell J, Zomerdijk JC (March 2007). "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription". The EMBO Journal. 26 (6): 1560–8. doi:10.1038/sj.emboj.7601601. PMC 1829371 . PMID 17318177.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166012 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031939 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa".

[6] Wang L, Bhattacharyya N, Chelsea DM, Escobar PF, Banerjee S (November 2004). "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype". Cancer Research. 64 (21): 7673–7. doi: 10.1158/0008-5472.CAN-04-2801 . PMID 15520167.

[7] Gorski JJ, Pathak S, Panov K, Kasciukovic T, Panova T, Russell J, Zomerdijk JC (March 2007). "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription". The EMBO Journal. 26 (6): 1560–8. doi:10.1038/sj.emboj.7601601. PMC 1829371 . PMID 17318177.

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