TERF2IP

TERF2IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FEX, 3K6G, 4RQI
Identifiers
Aliases	TERF2IP , DRIP5, RAP1, TERF2 interacting protein
External IDs	OMIM: 605061; MGI: 1929871; HomoloGene: 10357; GeneCards: TERF2IP; OMA:TERF2IP - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q23.1 Start 75,647,773 bp [1] End 75,761,872 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 112,738,030 bp [2] End 112,747,160 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 pars compacta pars reticulata superior vestibular nucleus pons internal globus pallidus lateral nuclear group of thalamus Brodmann area 9 superior frontal gyrus Top expressed in ventromedial nucleus supraoptic nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus lateral hypothalamus lumbar subsegment of spinal cord ventral tegmental area arcuate nucleus dorsal tegmental nucleus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding telomeric DNA binding protein binding G-rich strand telomeric DNA binding phosphatase binding Cellular component nuclear telomere cap complex nuclear envelope chromosome shelterin complex telomere nuclear chromosome Mre11 complex nucleus nucleoplasm cytosol nuclear body cytoplasm Biological process negative regulation of DNA recombination at telomere telomere maintenance via telomerase protection from non-homologous end joining at telomere regulation of double-strand break repair via homologous recombination transcription, DNA-templated positive regulation of peptidyl-serine phosphorylation protein localization to chromosome, telomeric region positive regulation of protein acetylation telomere maintenance via telomere lengthening positive regulation of NF-kappaB transcription factor activity positive regulation of I-kappaB kinase/NF-kappaB signaling telomere maintenance telomere capping negative regulation of protein phosphorylation regulation of transcription, DNA-templated regulation of telomere maintenance negative regulation of telomere maintenance positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54386 57321 Ensembl ENSG00000166848 ENSMUSG00000033430 UniProt Q9NYB0 Q91VL8 RefSeq (mRNA) NM_018975 NM_020584 RefSeq (protein) NP_061848 NP_065609 Location (UCSC) Chr 16: 75.65 – 75.76 Mb Chr 8: 112.74 – 112.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Not to be confused with Rap1.

Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene. ^{[5] [6]}

Interactions

TERF2IP has been shown to interact with Ku80, ^[7] Rad50 ^[7] and TERF2. ^{[5] [7] [8]} Upon interaction, TERF2IP/TERF2 complex has been shown to bind to telomeric junction sites with higher affinity ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000166848 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033430 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi: 10.1016/S0092-8674(00)80858-2 . PMID   10850490. S2CID   7956545.
6. "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
7. O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004). "The human Rap1 protein complex and modulation of telomere length". The Journal of Biological Chemistry. 279 (27): 28585–91. doi: 10.1074/jbc.M312913200 . PMID   15100233.
8. Zhu XD, Küster B, Mann M, Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nature Genetics. 25 (3): 347–52. doi:10.1038/77139. PMID   10888888. S2CID   6689794.
9. Arat NÖ, Griffith JD (December 2012). "Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere". The Journal of Biological Chemistry. 287 (50): 41583–94. doi: 10.1074/jbc.M112.415984 . PMC   3516710 . PMID   23086976.

Further reading

• Zhu XD, Küster B, Mann M, Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nature Genetics. 25 (3): 347–52. doi:10.1038/77139. PMID   10888888. S2CID   6689794.
• Hanaoka S, Nagadoi A, Yoshimura S, Aimoto S, Li B, de Lange T, Nishimura Y (September 2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains". Journal of Molecular Biology. 312 (1): 167–75. doi:10.1006/jmbi.2001.4924. PMID   11545594.
• Loayza D, De Lange T (June 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. Bibcode:2003Natur.423.1013L. doi:10.1038/nature01688. PMID   12768206. S2CID   4370276.
• Li B, de Lange T (December 2003). "Rap1 affects the length and heterogeneity of human telomeres". Molecular Biology of the Cell. 14 (12): 5060–8. doi:10.1091/mbc.E03-06-0403. PMC   284807 . PMID   14565979.
• Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T (December 2003). "ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes". Molecular Cell. 12 (6): 1489–98. doi: 10.1016/S1097-2765(03)00478-7 . PMID   14690602.
• O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004). "The human Rap1 protein complex and modulation of telomere length". The Journal of Biological Chemistry. 279 (27): 28585–91. doi: 10.1074/jbc.M312913200 . PMID   15100233.
• Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (July 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID   15181449. S2CID   11543383.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T (November 2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". The Journal of Biological Chemistry. 279 (45): 47264–71. doi: 10.1074/jbc.M409047200 . PMID   15316005.
• Liu D, O'Connor MS, Qin J, Songyang Z (December 2004). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". The Journal of Biological Chemistry. 279 (49): 51338–42. doi: 10.1074/jbc.M409293200 . PMID   15383534.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Antoine K, Ferbus D, Kolahgar G, Prospéri MT, Goubin G (July 2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". Journal of Cellular Biochemistry. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID   15838871. S2CID   10264323.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Wu Y, Zacal NJ, Rainbow AJ, Zhu XD (February 2007). "XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening". DNA Repair. 6 (2): 157–66. doi:10.1016/j.dnarep.2006.09.005. PMID   17055345.
• Bae NS, Baumann P (May 2007). "A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends". Molecular Cell. 26 (3): 323–34. doi: 10.1016/j.molcel.2007.03.023 . PMID   17499040.
• Cai Y, Kandula V, Kosuru R, Ye X, Irwin MG, Xia Z (Oct 2017). "Decoding telomere protein Rap1: its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy". Cell Cycle. 16 (19): 1765–1773. doi: 10.1080/15384101.2017.1371886 . PMC   5628636 . PMID   28853973.
• Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Xia Z (Mar 2021). "Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling". Theranostics. 11 (10): 4710–4727. doi: 10.7150/thno.51739 . PMC   7978321 . PMID   33754023.