TM4SF1

TM4SF1
Identifiers
Aliases	TM4SF1 , H-L6, L6, M3S1, TAAL6, transmembrane 4 L six family member 1
External IDs	OMIM: 191155 MGI: 104678 HomoloGene: 7409 GeneCards: TM4SF1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	149,377,692 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	57,209,409 bp
RNA expression pattern
	Top expressed in
	vena cava; ; parietal pleura; ; visceral pleura; ; germinal epithelium; ; lactiferous duct; ; pericardium; ; islet of Langerhans; ; lower lobe of lung; ; gallbladder; ; Achilles tendon;
	Top expressed in
	right lung lobe; ; carotid body; ; atrioventricular valve; ; semi-lunar valve; ; aortic valve; ; ascending aorta; ; endocardial cushion; ; left lung; ; ankle joint; ; atrium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; molecular function ;
Cellular component	integral component of plasma membrane ; membrane ; integral component of membrane ;
Biological process	biological process ; blastocyst formation ;
	Sources:Amigo / QuickGO
Orthologs
	4071
	17112
	ENSG00000169908
	ENSMUSG00000027800
	P30408
	Q64302
	NM_014220
	NM_008536 ; NM_001355130
	NP_055035
	NP_032562 ; NP_001342059
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 03, 2023

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.^[6]

Marker gene for alveolar epithelial progenitors

TM4SF1 has been identified as a marker of Wnt-responsive alveolar epithelial progenitor cells, and a marker of alveolar repair in injured regions of the lungs.^[7] It has also been found hypomethylated and upregulated in asthma, with potential prognostic value (AUROC: 0.769).^[8]

Related Research Articles

CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.

CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.

CD151 molecule, also known as CD151, is a human gene.

CD81 molecule, also known as CD81, is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1, and Tetraspanin-28 (Tspan-28).

CD82, or KAI1, is a human protein encoded by the CD82 gene.

CD6 is a human protein encoded by the CD6 gene.

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.

Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.

Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.

Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.

Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.

CKLF like MARVEL transmembrane domain-containing 6, previously termed chemokine-like factor superfamily 6, is a transmembrane protein encoded in humans by the CMTM6 gene. This gene is located in band 22.3 on the short arm of chromosome 3. CMTM6 protein belongs to the CKLF-like MARVEL transmembrane domain-containing family of proteins. This family consist of 9 member proteins: CKLF and CMTM1 through CMTM8. The CMTM family proteins are involved in autoimmune diseases, cardiovascular diseases, the male reproductive system, haematopoiesis, and cancer development. CMTM6 protein regulates immune responses to normal and abnormal cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169908 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027800 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. Bibcode:1992PNAS...89.3503M. doi: 10.1073/pnas.89.8.3503 . PMC 48896 . PMID 1565644.
1 2 "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".
↑ Zacharias, William J.; Frank, David B.; Zepp, Jarod A.; Morley, Michael P.; Alkhaleel, Farrah A.; Kong, Jun; Zhou, Su; Cantu, Edward; Morrisey, Edward E. (2018-03-08). "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor". Nature. 555 (7695): 251–255. doi:10.1038/nature25786. ISSN 1476-4687. PMC 6020060 . PMID 29489752.
↑ Wang, Zongling; Wang, Lizhi; Dai, Lina; Wang, Yanan; Li, Erhong; An, Shuyuan; Wang, Fengliang; Liu, Dan; Pan, Wen (2022-12-22). "Identification of candidate aberrant differentially methylated/expressed genes in asthma". Allergy, Asthma, and Clinical Immunology: Official Journal of the Canadian Society of Allergy and Clinical Immunology. 18 (1): 108. doi:10.1186/s13223-022-00744-5. ISSN 1710-1484. PMC 9784293 . PMID 36550577.

Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Marken JS, Bajorath J, Edwards CP, Farr AG, Schieven GL, Hellström I, Hellström KE, Aruffo A (Mar 1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody". The Journal of Biological Chemistry. 269 (10): 7397–401. doi: 10.1016/S0021-9258(17)37298-8 . PMID 7510285.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, Schröder JP (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5): 329–34. doi:10.1007/BF00189229. PMID 8168850. S2CID 22971645.
Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J (Dec 2000). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Molecular Biology of the Cell. 11 (12): 4217–25. doi:10.1091/mbc.11.12.4217. PMC 15068 . PMID 11102519.
Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J (Jul 2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Experimental Cell Research. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.
Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, Yagihashi A, Watanabe N (Dec 2001). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". The American Journal of Gastroenterology. 96 (12): 3457–8. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983. S2CID 31864317.
Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clinical Cancer Research. 9 (7): 2807–16. PMID 12855661.
Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". International Journal of Cancer. 116 (2): 243–52. doi: 10.1002/ijc.21089 . PMID 15812828. S2CID 26010618.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder W, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC (Jun 2015). "Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature". Molecular Cancer Therapeutics. 14 (8): 1868–76. doi: 10.1158/1535-7163.MCT-15-0188 . PMID 26089370.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169908 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027800 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1565644-5] Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. Bibcode:1992PNAS...89.3503M. doi: 10.1073/pnas.89.8.3503 . PMC 48896 . PMID 1565644.

[entrez-6] 1 2 "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".

[7] Zacharias, William J.; Frank, David B.; Zepp, Jarod A.; Morley, Michael P.; Alkhaleel, Farrah A.; Kong, Jun; Zhou, Su; Cantu, Edward; Morrisey, Edward E. (2018-03-08). "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor". Nature. 555 (7695): 251–255. doi:10.1038/nature25786. ISSN 1476-4687. PMC 6020060 . PMID 29489752.

[8] Wang, Zongling; Wang, Lizhi; Dai, Lina; Wang, Yanan; Li, Erhong; An, Shuyuan; Wang, Fengliang; Liu, Dan; Pan, Wen (2022-12-22). "Identification of candidate aberrant differentially methylated/expressed genes in asthma". Allergy, Asthma, and Clinical Immunology: Official Journal of the Canadian Society of Allergy and Clinical Immunology. 18 (1): 108. doi:10.1186/s13223-022-00744-5. ISSN 1710-1484. PMC 9784293 . PMID 36550577.

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TM4SF1

Contents

Function

Marker gene for alveolar epithelial progenitors

Related Research Articles

References

Further reading