| TMUB2 | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | TMUB2 , FP2653, transmembrane and ubiquitin like domain containing 2 | ||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1919303; HomoloGene: 18581; GeneCards: TMUB2; OMA:TMUB2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||
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Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene. [4] [5] [6]
TMUB2 maps on the human chromosome 17, at locus 17q21.31. [6] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right. [7] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants. [8]
TMUB2 is likely ubiquitously expressed throughout the human body. [9] It has a high expression level that is 2.9 times higher than other human genes. [10] [11]
The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions. [12] These will likely vary in orthologs.
TMUB1 is the only paralog of TMUB2. [13] [14] These proteins share a 38% identity and 51% similarity. [15]
The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species. [15]
| Species | Common name | Accession number | Sequence length (aa) | Sequence identity | Sequence similarity |
|---|---|---|---|---|---|
| Pan troglodytes | Chimpanzee | XP_003953053.1 | 301 | 100% | 100% |
| Felis Catus | Cat | XP_003997025.1 | 322 | 95% | 95% |
| Mus Musculus | Mouse | AAH29841.2 | 319 | 85% | 88% |
| Alligator Mississippiensus | Alligator | XP_006271613.1 | 306 | 61% | 71% |
| Haliaeetus leucocephalus | Bald Eagle | XP_010559728 | 301 | 59% | 70% |
| Danio rerio | Zebrafish | NP_001005573.1 | 291 | 47% | 60% |
| Acromyrmex echinatior | Ant | XP_011049429.1 | 354 | 23% | 42% |
| Nannochloropsis Gaditana* | Algae | EWM26843.1 | 476 | 41% | 54% |
| Coccidioides immitis RS* | Pathogenic Fungus | XP_001242306.1 | 418 | 38% | 50% |
*Limited Query Coverage
In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2. [16] [17] [18] [19] Other proposed interactions include BCL2L13 (BCL2-like 13), [20] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein), [20] and UBQLN1 (Ubiquilin-1). [20] [21] [22]
Ras-related protein Rab-14 is a protein that in humans is encoded by the RAB14 gene.
SUMO1/sentrin/SMT3 specific peptidase 3, also known as SENP3, is a protein which in humans is encoded by the SENP3 gene.
Alpha-1,2-mannosyltransferase ALG9 is an enzyme that in humans is encoded by the ALG9 gene.
40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.
60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.
Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.
E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.
E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.
Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.
Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.
Growth hormone-inducible transmembrane protein (GHITM), also known as transmembrane BAX inhibitor motif containing protein 5 (TMBIM5), is a protein that in humans is encoded by the GHITM gene on chromosome 10. It is a member of the BAX inhibitor motif containing (TMBIM) family and localizes to the inner mitochondrial membrane (IMM), as well as the endoplasmic reticulum (ER), where it plays a role in apoptosis through mediating mitochondrial morphology and cytochrome c release. Through its apoptotic function, GHITM may be involved in tumor metastasis and innate antiviral responses.
Ubiquitin-associated domain-containing protein 1 is a protein that in humans is encoded by the UBAC1 gene.
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.
Mitochondrial fission regulator 1 like is a protein that in humans is encoded by the MTFR1L gene.
E3 ubiquitin-protein ligase LRSAM1, previously known as Tsg101-associated ligase (Tal), is an enzyme that in humans is encoded by the LRSAM1 gene.
Low-density lipoprotein receptor-related protein 10 is a protein that in humans is encoded by the LRP10 gene.
Importin-11 is a protein that in humans is encoded by the IPO11 gene.
E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene. It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins. MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.
Vacuolar protein sorting-associated protein 13D is a protein that in humans is encoded by the VPS13D gene.
Enkurin domain-containing protein 1 is a protein that in humans is encoded by the ENKD1 gene.
