TREX2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TREX2 , three prime repair exonuclease 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300370 MGI: 1346343 HomoloGene: 8046 GeneCards: TREX2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene. [5] [6]
This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [6]
Mutations in this gene may lead to Aicardi-Goutieres syndrome
Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a member of the RecQ Helicase family. Helicase enzymes generally unwind and separate double-stranded DNA. These activities are necessary before DNA can be copied in preparation for cell division. Helicase enzymes are also critical for making a blueprint of a gene for protein production, a process called transcription. Further evidence suggests that Werner protein plays a critical role in repairing DNA. Overall, this protein helps maintain the structure and integrity of a person's DNA.
DNA polymerase lambda, also known as Pol λ, is an enzyme found in all eukaryotes. In humans, it is encoded by the POLL gene.
Exonuclease 1 is an enzyme that in humans is encoded by the EXO1 gene.
PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDK11B gene.
Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.
Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene.
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.
DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.
DNA excision repair protein ERCC-8 is a protein that in humans is encoded by the ERCC8 gene.
Protein reversionless 3-like (REV3L) also known as DNA polymerase zeta catalytic subunit (POLZ) is an enzyme that in humans is encoded by the REV3L gene.
REX2, RNA exonuclease 2 homolog , also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.
Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.
RNA exonuclease 4 is an enzyme that in humans is encoded by the REXO4 gene.
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.
CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene.
DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.
Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.
Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.
DNA cross-link repair 1B protein is a protein that in humans is encoded by the DCLRE1B gene.
DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.