TXNDC2

TXNDC2
Identifiers
Aliases	TXNDC2 , SPTRX, SPTRX1, thioredoxin domain containing 2
External IDs	OMIM: 617790 MGI: 2389312 HomoloGene: 41856 GeneCards: TXNDC2
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,889,275 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	65,949,163 bp
RNA expression pattern
	Top expressed in
	sperm; ; brain stem; ; muscle tissue; ; medulla oblongata; ; stromal cell of endometrium; ; upper respiratory tract; ; monocyte; ; metanephros; ; blood; ; smooth muscle tissue;
	Top expressed in
	seminiferous tubule; ; secondary oocyte; ; spermatid; ; paraventricular nucleus of hypothalamus; ; spermatocyte; ; adrenal gland; ; ovary; ; cumulus cell; ; cervix; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-disulfide reductase activity ; thioredoxin-disulfide reductase activity ; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ; protein-disulfide reductase (NAD(P)) activity ;
Cellular component	cytoplasm ;
Biological process	multicellular organism development ; cellular response to oxidative stress ; cell differentiation ; glycerol ether metabolic process ; cell redox homeostasis ; spermatogenesis ; cellular oxidant detoxification ;
	Sources:Amigo / QuickGO
Orthologs
	84203
	213272
	ENSG00000168454
	ENSMUSG00000050612
	Q86VQ3
	Q6P902
	NM_032243 ; NM_001098529
	NM_001146002 ; NM_153519
	NP_001091999 ; NP_115619
	NP_001139474 ; NP_705739 ; NP_001391021 ; NP_001391027
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 13, 2024

Thioredoxin domain-containing protein 2 is a protein that in humans is encoded by the TXNDC2 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168454 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050612 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
↑ Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G (Aug 2001). "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa" (PDF). J Biol Chem. 276 (34): 31567–74. doi: 10.1074/jbc.M101760200 . PMID 11399755. S2CID 8214150.
↑ "Entrez Gene: TXNDC2 thioredoxin domain containing 2 (spermatozoa)".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jiménez A, Johansson C, Ljung J, et al. (2002). "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity". FEBS Lett. 530 (1–3): 79–84. Bibcode:2002FEBSL.530...79J. doi:10.1016/S0014-5793(02)03417-8. hdl: 10261/47334 . PMID 12387870. S2CID 24685421.
Sadek CM, Damdimopoulos AE, Pelto-Huikko M, et al. (2002). "Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells". Genes Cells. 6 (12): 1077–90. doi:10.1046/j.1365-2443.2001.00484.x. hdl: 10261/47418 . PMID 11737268. S2CID 20869820.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168454 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050612 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.

[pmid11399755-6] Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G (Aug 2001). "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa" (PDF). J Biol Chem. 276 (34): 31567–74. doi: 10.1074/jbc.M101760200 . PMID 11399755. S2CID 8214150.

[entrez-7] "Entrez Gene: TXNDC2 thioredoxin domain containing 2 (spermatozoa)".

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TXNDC2

Related Research Articles

References

Further reading