TXNDC12

Last updated
TXNDC12
Protein TXNDC12 PDB 1sen.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TXNDC12 , AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDs OMIM: 609448; MGI: 1913323; HomoloGene: 41074; GeneCards: TXNDC12; OMA:TXNDC12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015913

NM_025334

RefSeq (protein)

NP_056997

NP_079610

Location (UCSC) Chr 1: 52.02 – 52.06 Mb Chr 4: 108.69 – 108.72 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene. [5] [6] [7]

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors [8] (Liu et al., 2003).[supplied by OMIM] [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117862 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028567 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
  6. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
  7. 1 2 "Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)".
  8. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi: 10.1186/1479-7364-6-6 . PMC   3500226 . PMID   23245351.

Further reading