TXNDC12

TXNDC12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SEN, 2K8V
Identifiers
Aliases	TXNDC12 , AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDs	OMIM: 609448 MGI: 1913323 HomoloGene: 41074 GeneCards: TXNDC12
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 52,020,131 bp [1] End 52,055,191 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 108,691,798 bp [2] End 108,719,324 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte rectum stromal cell of endometrium body of pancreas islet of Langerhans placenta gallbladder lymph node smooth muscle tissue appendix Top expressed in medial ganglionic eminence spermatocyte endocardial cushion dermis calvaria atrium atrioventricular valve yolk sac abdominal wall Epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein-disulfide reductase (glutathione) activity protein binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cell redox homeostasis cell differentiation negative regulation of cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51060 66073 Ensembl ENSG00000117862 ENSMUSG00000028567 UniProt O95881 Q9CQU0 RefSeq (mRNA) NM_015913 NM_025334 RefSeq (protein) NP_056997 NP_079610 Location (UCSC) Chr 1: 52.02 – 52.06 Mb Chr 4: 108.69 – 108.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene. ^{[5] [6] [7]}

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors ^[8] (Liu et al., 2003).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000117862 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028567 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
6. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
7. "Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)".
8. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC   3500226 . PMID   23245351.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Alanen HI, Williamson RA, Howard MJ, et al. (2003). "Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member". J. Biol. Chem. 278 (31): 28912–20. doi: 10.1074/jbc.M304598200 . PMID   12761212.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Liu F, Rong YP, Zeng LC, et al. (2004). "Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein". Gene. 315: 71–8. doi:10.1016/S0378-1119(03)00732-7. PMID   14557066.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.