Tilorone

Last updated
Tilorone
Tilorone.svg
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration 		By mouth (tablets)
ATC code
Pharmacokinetic data
Bioavailability 60%
Protein binding ~80%
Metabolism Nil
Elimination half-life 48 hours
Excretion Feces (70%), urine (9%) [1]
Identifiers
  • 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C25H34N2O3
Molar mass 410.558 g·mol−1
3D model (JSmol)
  • CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
  • InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 X mark.svgN
  • Key:MPMFCABZENCRHV-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer. [2] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice. [3] It shows activity against Eastern equine encephalitis and related viruses. [4]

Contents

Pharmacology

Tilorone activates the production of interferon. [2]

See also

References

  1. ↑ "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.
  2. 1 2 Stringfellow DA, Glasgow LA (August 1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrobial Agents and Chemotherapy. 2 (2): 73–78. doi:10.1128/aac.2.2.73. PMC   444270 . PMID   4670490.
  3. ↑ Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, et al. (February 2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC   5786809 . PMID   29133569.
  4. ↑ Ogorek TJ, Golden JE (February 2023). "Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses". Viruses. 15 (2): 413. doi: 10.3390/v15020413 . PMC   9958955 . PMID   36851628.
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