Translin-associated factor X

TSNAX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PJA, 3QB5
Identifiers
Aliases	TSNAX , TRAX, translin-associated factor X, translin associated factor X, C3PO
External IDs	OMIM: 602964 MGI: 1855672 HomoloGene: 4374 GeneCards: TSNAX
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.2 Start 231,528,541 bp [1] End 231,566,524 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 E2|8 73.1 cM Start 125,739,736 bp [2] End 125,760,931 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura secondary oocyte islet of Langerhans visceral pleura germinal epithelium monocyte Achilles tendon human penis retinal pigment epithelium seminal vesicula Top expressed in superior frontal gyrus entorhinal cortex temporal muscle prefrontal cortex triceps brachii muscle nucleus accumbens Region I of hippocampus proper amygdala extensor digitorum longus muscle cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding metal ion binding RNA binding single-stranded DNA binding endoribonuclease activity A2A adenosine receptor binding protein-containing complex binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol Golgi apparatus nucleus Biological process multicellular organism development cell differentiation spermatogenesis protein transport production of siRNA involved in RNA interference RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7257 53424 Ensembl ENSG00000116918 ENSMUSG00000056820 UniProt Q99598 Q9QZE7 RefSeq (mRNA) NM_005999 NM_016909 RefSeq (protein) NP_005990 NP_058605 Location (UCSC) Chr 1: 231.53 – 231.57 Mb Chr 8: 125.74 – 125.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene. ^{[5] [6]}

Function

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. ^[6] Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC). ^[7]

Interactions

TSNAX has been shown to interact with C1D. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000116918 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056820 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aoki K, Ishida R, Kasai M (Jan 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters. 401 (2–3): 109–12. doi:10.1016/S0014-5793(96)01444-5. PMID   9013868. S2CID   46704829.
6. "Entrez Gene: TSNAX translin-associated factor X".
7. Ha M, Kim VN (Aug 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID   25027649. S2CID   205495632.
8. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science. 115 (Pt 1): 207–16. doi:10.1242/jcs.115.1.207. hdl: 11693/24740 . PMID   11801738.

Further reading

• Millar JK, Christie S, Semple CA, Porteous DJ (Jul 2000). "Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia". Genomics. 67 (1): 69–77. doi:10.1006/geno.2000.6239. PMID   10945471.
• Meng G, Aoki K, Tokura K, Nakahara K, Inazawa J, Kasai M (2000). "Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X". Journal of Human Genetics. 45 (5): 305–8. doi: 10.1007/s100380070022 . PMID   11043515.
• Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (Apr 2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". The Journal of Biological Chemistry. 276 (16): 13256–63. doi: 10.1074/jbc.M009707200 . PMID   11278549.
• Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science. 115 (Pt 1): 207–16. doi:10.1242/jcs.115.1.207. hdl: 11693/24740 . PMID   11801738.
• Bray JD, Chennathukuzhi VM, Hecht NB (Jun 2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID   12036294.
• Wu RF, Osatomi K, Terada LS, Uyeda K (Dec 2003). "Identification of Translin/Trax complex as a glucose response element binding protein in liver". Biochimica et Biophysica Acta (BBA) - General Subjects. 1624 (1–3): 29–35. doi:10.1016/j.bbagen.2003.09.002. PMID   14642810.
• Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB (Mar 2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation". The Journal of Biological Chemistry. 279 (13): 12605–14. doi: 10.1074/jbc.M313133200 . PMID   14711818.
• Gocke CB, Yu H, Kang J (Feb 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi: 10.1074/jbc.M411718200 . PMID   15561718.
• Thomson PA, Wray NR, Millar JK, Evans KL, Hellard SL, Condie A, Muir WJ, Blackwood DH, Porteous DJ (Jul 2005). "Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population". Molecular Psychiatry. 10 (7): 657–68, 616. doi:10.1038/sj.mp.4001669. PMID   15838535. S2CID   144686652.
• Gupta GD, Makde RD, Kamdar RP, D'Souza JS, Kulkarni MG, Kumar V, Rao BJ (Jun 2005). "Co-expressed recombinant human Translin-Trax complex binds DNA". FEBS Letters. 579 (14): 3141–6. doi: 10.1016/j.febslet.2005.05.007 . PMID   15919079.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : Q99598 (Translin-associated protein X) at the PDBe-KB .