Treponema paraluiscuniculi

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Treponema paraluiscuniculi
Scientific classification Red Pencil Icon.png
Domain: Bacteria
Phylum: Spirochaetes
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species:
T. paraluiscuniculi
Binomial name
Treponema paraluiscuniculi
(Jacobsthal, 1920) Smibert, 1974
Synonyms
  • Treponema cuniculi

Treponema paraluiscuniculi is a Gram-negative, spiral-shaped bacterium. [1] It is the etiologic agent of "Rabbit Syphilis". This condition occurs occasionally in laboratory rabbits, pet rabbits, and wild rabbits, but is not considered a significant cause of morbidity.

The organism is most commonly spread via the venereal route, however, extragenital contact transmission can occur. The lesions associated with Treponema paraluiscuniculi include edema, erythema, and papules of the mucocutaneous junctions of the vulva, prepuce, anal region, muzzle, and periorbital region that progress to ulceration and crusting. Histologically, these areas are characterized by hyperplasia of the epidermis, necrosis of epithelial cells, erosion and ulceration, and an inflammatory infiltrate composed of plasma cells, macrophages, and heterophils.

The recommended method of testing for the bacterium is skin scrape with wet mount and dark field microscopy. The organisms are also argyrophilic and will be highlighted in histologic section by a silver stain (such as Warthin-Starry). Differential diagnoses include Pasturella infection, moist dermatitis, and traumatic injury. [2] [3]

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<i>Treponema pallidum</i> Species of bacterium

Treponema pallidum is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel, and yaws. It is transmitted only amongst humans. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. T. pallidum's lack of either tricarboxylic acid cycle or oxidative phosphorylation results in minimal metabolic activity. The treponemes have a cytoplasmic and an outer membrane. Using light microscopy, treponemes are visible only by using dark field illumination. Treponema pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct associated disease.

Chancre Genital ulcer

A chancre is a painless genital ulcer most commonly formed during the primary stage of syphilis. This infectious lesion forms approximately 21 days after the initial exposure to Treponema pallidum, the gram-negative spirochaete bacterium yielding syphilis. Chancres transmit the sexually transmissible disease of syphilis through direct physical contact. These ulcers usually form on or around the anus, mouth, penis and vagina. Chancres may diminish between four and eight weeks without the application of medication.

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References

  1. "Treponema paraluiscuniculi (Jacobsthal, 1920) Smibert, 1974". Species 2000 & ITIS Catalogue of Life . Species 2000: Naturalis, Leiden, the Netherlands. Retrieved 28 May 2021.
  2. Percy, Dean H.; Griffey, Stephen; Barthold, Stephen (2016). Pathology of laboratory rodents and rabbits (Fourth ed.). Ames, Iowa: Wiley Blackwell. p. 287. ISBN   978-1-1188-2424-5.
  3. "Treponema paraluiscuniculi" (PDF). criver.com/resources. Charles River. Retrieved 27 May 2021.