Trisodium citrate

Last updated
Sodium citrate
Natriumcitrat V1.svg
Trisodium Citrate taken with my iPhone SE in my kitchen.jpg
Names
Preferred IUPAC name
Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Other names
Sodium citrate
Trisodium citrate
Citrosodine
Trisodium salt
E331
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.000.614 OOjs UI icon edit-ltr-progressive.svg
E number E331iii (antioxidants, ...)
PubChem CID
RTECS number
  • GE8300000
UNII
  • InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 X mark.svgN
    Key: HRXKRNGNAMMEHJ-UHFFFAOYSA-K X mark.svgN
  • InChI=1/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    Key: HRXKRNGNAMMEHJ-DFZHHIFOAL
  • C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]
Properties
Na3C6H5O7
Molar mass 258.06 g/mol (anhydrous), 294.10 g/mol (dihydrate)
AppearanceWhite crystalline powder
Density 1.7 g/cm3
Melting point >300 °C (572 °F; 573 K) (hydrates lose water ca. 150 °C)
Boiling point Decomposes
Anhydrous form:57 g/100 g H2O (25 °C) [1] Pentahydrate form: 92 g/100 g H2O (25 °C) [2]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Irritant
NFPA 704 (fire diamond)
NFPA 704.svgHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
0
0
Lethal dose or concentration (LD, LC):
1548 mg/kg (intraperitoneal, rat) [3]
Safety data sheet (SDS) External MSDS
Related compounds
Related compounds
Monosodium citrate
Disodium citrate
Calcium citrate
Citric acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN  verify  (what is  Yes check.svgYX mark.svgN ?)

Trisodium citrate is a chemical compound with the molecular formula Na3C6H5O7. It is sometimes referred to simply as "sodium citrate", though sodium citrate can refer to any of the three sodium salts of citric acid. It possesses a saline, mildly tart taste, and is a mild alkali.

Contents

Uses

Foods

Sodium citrate is chiefly used as a food additive, usually for flavor or as a preservative. Its E number is E331. Sodium citrate is employed as a flavoring agent in certain varieties of club soda. It is common as an ingredient in bratwurst, and is also used in commercial ready-to-drink beverages and drink mixes, contributing a tart flavor. It is found in gelatin mix, ice cream, yogurt, jams, sweets, milk powder, processed cheeses, carbonated beverages, wine, and butter chicken, [4] amongst others. Because the elements in Na3C6H5O7 spell "Na C H O", "Nacho Cheese" is a convenient mnemonic for trisodium citrate's chemical formula. [5]

Sodium citrate can be used as an emulsifying stabilizer when making cheese. It allows the cheese to melt without becoming greasy by stopping the fats from separating.

Buffering

Speciation diagram for a 10-millimolar solution of citric acid. The violet curve corresponds to the trisodium citrate. Citric acid speciation.svg
Speciation diagram for a 10-millimolar solution of citric acid. The violet curve corresponds to the trisodium citrate.

As a conjugate base of a weak acid, citrate can perform as a buffering agent or acidity regulator, resisting changes in pH. It is used to control acidity in some substances, such as gelatin desserts. It can be found in the milk minicontainers used with coffee machines. The compound is the product of antacids, such as Alka-Seltzer, when they are dissolved in water.[ citation needed ] The pH range of a solution of 5 g/100 ml water at 25 °C is 7.5 to 9.0. It is added to many commercially packaged dairy products to control the pH impact of the gastrointestinal system of humans[ citation needed ], mainly in processed products such as cheese and yogurt, although it also has beneficial effects on the physical gel microstructure. [6]

Chemistry

Sodium citrate is a component in Benedict's qualitative solution, often used in organic analysis to detect the presence of reducing sugars such as glucose.

Medicine

In 1914, the Belgian doctor Albert Hustin and the Argentine physician and researcher Luis Agote successfully used sodium citrate as an anticoagulant in blood transfusions, with Richard Lewisohn determining its correct concentration in 1915. It continues to be used in blood-collection tubes and for the preservation of blood in blood banks. The citrate ion chelates calcium ions in the blood by forming calcium citrate complexes, disrupting the blood clotting mechanism. Recently, trisodium citrate has also been used as a locking agent in vascath and haemodialysis lines instead of heparin due to its lower risk of systemic anticoagulation. [7]

In 2003, Ööpik et al. showed the use of sodium citrate (0.5 g/kg body weight) improved running performance over 5 km by 30 seconds. [8]

Sodium citrate is used to relieve discomfort in urinary-tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative. It is a major component of the WHO oral rehydration solution.

It is used as an antacid, especially prior to anaesthesia, for caesarian section procedures to reduce the risks associated with the aspiration of gastric contents.

Boiler descaling

Sodium citrate is a particularly effective agent for removal of carbonate scale from boilers without removing them from operation [9] and for cleaning automobile radiators. [10]

See also

Related Research Articles

<span class="mw-page-title-main">Antacid</span> Substance that relieves stomach problems

An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn, indigestion, or an upset stomach. Some antacids have been used in the treatment of constipation and diarrhea. Marketed antacids contain salts of aluminum, calcium, magnesium, or sodium. Some preparations contain a combination of two salts, such as magnesium carbonate and aluminum hydroxide.

<span class="mw-page-title-main">Citric acid</span> Weak organic acid

Citric acid is an organic compound with the skeletal formula HOC(CO2H)(CH2CO2H)2. It is a colorless weak organic acid. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in the metabolism of all aerobic organisms.

<span class="mw-page-title-main">Trisodium phosphate</span> Chemical compound

Trisodium phosphate (TSP) is an inorganic compound with the chemical formula Na3PO4. It is a white, granular or crystalline solid, highly soluble in water, producing an alkaline solution. TSP is used as a cleaning agent, builder, lubricant, food additive, stain remover, and degreaser.

<span class="mw-page-title-main">Calcium citrate</span> Chemical compound

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements. Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass. The tetrahydrate occurs in nature as the mineral Earlandite.

ATC code B05Blood substitutes and perfusion solutions is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup B05 is part of the anatomical group B Blood and blood forming organs.

<span class="mw-page-title-main">Curdling</span> Breaking of an emulsion or colloid into large parts of different composition

Curdling is the breaking of an emulsion or colloid into large parts of different composition through the physio-chemical processes of flocculation, creaming, and coalescence. Curdling is purposeful in the production of cheese curd and tofu; undesirable in the production of a sauce, cheese fondue or a custard.

<span class="mw-page-title-main">Potassium citrate</span> Chemical compound

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid with the molecular formula K3C6H5O7. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste. It contains 38.28% potassium by mass. In the monohydrate form, it is highly hygroscopic and deliquescent.

<span class="mw-page-title-main">Easy Cheese</span> Canned processed cheese product

Easy Cheese is the trademark for a processed cheese spread product distributed by Mondelēz International. It is also commonly referred to by generic terms such as "spray cheese", "squirt cheese", "cheese in a can", and/or "cheese cans". Easy Cheese is packaged in a metal can filled with air covered with a plastic cap that reveals a straight, flexible nozzle where the cheese is extruded.

<span class="mw-page-title-main">Calcium lactate</span> Chemical compound

Calcium lactate is a white crystalline salt with formula C
6
H
10
CaO
6
, consisting of two lactate anions H
3
C
(CHOH)CO
2
for each calcium cation Ca2+
. It forms several hydrates, the most common being the pentahydrate C
6
H
10
CaO
6
·5H
2
O
.

<span class="mw-page-title-main">Ammonium ferric citrate</span> Highly soluble organic compound, food ingredient

Ammonium ferric citrate has the formula [NH4]y[Fex(C6H4O7)]. The iron in this compound is trivalent. All three carboxyl groups and the central hydroxyl group of citric acid are deprotonated. A distinguishing feature of this compound is that it is very soluble in water, in contrast to ferric citrate which is not very soluble.

Acid-citrate-dextrose or acid-citrate-dextrose solution, also known as anticoagulant-citrate-dextrose or anticoagulant-citrate-dextrose solution is any solution of citric acid, sodium citrate, and dextrose in water. It is mainly used as an anticoagulant to preserve blood specimens required for tissue typing. It is also used during procedures such as plasmapheresis instead of heparin.

<span class="mw-page-title-main">Monosodium citrate</span> Chemical compound

Monosodium citrate, more correctly, sodium dihydrogen citrate (Latin: natrium citricum acidulatum), is an acid salt of citric acid. Disodium citrate and trisodium citrate are also known. It can be prepared by partial neutralisation of citric acid with an aqueous solution of sodium bicarbonate or carbonate. It has a slightly acidic taste.

<span class="mw-page-title-main">Disodium citrate</span> Chemical compound

Disodium citrate, also known as disodium hydrogen citrate, (Neo-Alkacitron) and sesquihydrate, is an acid salt of citric acid with the chemical formula Na2C6H6O7. It is used as an antioxidant in food and to improve the effects of other antioxidants. It is also used as an acidity regulator and sequestrant. Typical products include gelatin, jam, sweets, ice cream, carbonated beverages, milk powder, wine, and processed cheeses.

<span class="mw-page-title-main">Sodium lactate</span> Chemical compound

Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as maize or beets, and then, by neutralizing the resulting lactic acid to create a compound having the formula NaC3H5O3.

<span class="mw-page-title-main">Cleaning agent</span> Substance used to remove dirt or other contaminants

Cleaning agents or hard-surface cleaners are substances used to remove dirt, including dust, stains, foul odors, and clutter on surfaces. Purposes of cleaning agents include health, beauty, removing offensive odors, and avoiding the spread of dirt and contaminants to oneself and others. Some cleaning agents can kill bacteria and clean at the same time. Others, called degreasers, contain organic solvents to help dissolve oils and fats.

<span class="mw-page-title-main">Citric acid/potassium-sodium citrate</span> Drug used in the treatment of metabolic acidosis

Citric acid/potassium-sodium citrate is a drug used in the treatment of metabolic acidosis. It is made up of citrate, a sodium cation and potassium cation.

Sodium citrate may refer to any of the sodium salts of citric acid :

<span class="mw-page-title-main">Sour cream</span> Fermented dairy product

Sour cream is a dairy product obtained by fermenting regular cream with certain kinds of lactic acid bacteria. The bacterial culture, which is introduced either deliberately or naturally, sours and thickens the cream. Its name comes from the production of lactic acid by bacterial fermentation, which is called souring. Crème fraîche is one type of sour cream with a high fat content and less sour taste.

Alkali citrate is an inhibitor of kidney stones. It is used to increase urine citrate levels - this prevents calcium oxalate stones by binding to calcium and inhibiting its binding to oxalate. It is also used to increase urine pH - this prevents uric acid stones and cystine stones.

References

  1. "Sodium citrate | 68-04-2" . Retrieved 14 December 2023.
  2. "CRC Handbook of Chemistry and Physics" . Retrieved 22 November 2013.
  3. Chambers, Michael. "ChemIDplus - 68-04-2 - HRXKRNGNAMMEHJ-UHFFFAOYSA-K - Sodium citrate anhydrous - Similar structures search, synonyms, formulas, resource links, and other chemical information". chem.nlm.nih.gov.
  4. "Permitted Emulsifying Salt (E331)". 5 March 2018.
  5. "Make a Perfectly Creamy Cheese Sauce Without Resorting to Velveeta". Christopher Kimball’s Milk Street. Retrieved 2024-09-20.
  6. Ozcan-Yilsay, T; Lee, W.-J. (2007). "Effect of Trisodium Citrate on Rheological and Physical Properties and Microstructure of Yogurt". Journal of Dairy Science. 90 (4): 1644–1652. doi: 10.3168/jds.2006-538 . PMID   17369204.
  7. "Locking Solutions for Hemodialysis Catheters" (PDF).
  8. V. Ööpik; I. Saaremets; L. Medijainen; K. Karelson; T. Janson; S. Timpmann (2003). "Effects of sodium citrate ingestion before exercise on endurance performance in well trained college runners". British Journal of Sports Medicine. 37 (6): 485–489. doi:10.1136/bjsm.37.6.485. PMC   1724692 . PMID   14665584.
  9. U.S. patent 3,095,862
  10. "MSDS" (PDF).