Trithionate hydrolase

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trithionate hydrolase
EC number
CAS number 115004-90-5
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ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a trithionate hydrolase (EC is an enzyme that catalyzes the chemical reaction [1] [2]

trithionate + H2O thiosulfate + sulfate + 2 H+

Thus, the two substrates of this enzyme are trithionate and H2O, whereas its 3 products are thiosulfate, sulfate, and H+.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-sulfur bonds. The systematic name of this enzyme class is trithionate thiosulfohydrolase. This enzyme participates in sulfur metabolism.

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Microbial oxidation of sulfur

Microbial oxidation of sulfur is the oxidation of sulfur by microorganisms to produce energy. The oxidation of inorganic compounds is the strategy primarily used by chemolithotrophic microorganisms to obtain energy in order to build their structural components, survive, grow and reproduce. Some inorganic forms of reduced sulfur, mainly sulfide (H2S/HS) and elemental sulfur (S0), can be oxidized by chemolithotrophic sulfur-oxidizing prokaryotes, usually coupled to the reduction of oxygen (O2) or nitrate (NO3).


  1. Lu WP, Kelly DP (1988). "Cellular location and partial purification of the 'thiosulphate-oxidizing enzyme' and 'trithionate hydrolase' from Thiobacillus tepidarius". J. Gen. Microbiol. 134: 877–885. doi: 10.1099/00221287-134-4-877 .
  2. Trudinger PA (1964). "The metabolism of trithionate by Thiobacillus X". Aust. J. Biol. Sci. 17: 459–468.