UBE4B

UBE4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KRE, 3L1X, 3L1Z
Identifiers
Aliases	UBE4B , E4, HDNB1, UBOX3, UFD2, UFD2A, ubiquitination factor E4B
External IDs	OMIM: 613565 MGI: 1927086 HomoloGene: 107623 GeneCards: UBE4B
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.22 Start 10,032,832 bp [1] End 10,181,239 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 E2|4 79.08 cM Start 149,328,416 bp [2] End 149,426,749 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle cerebellar hemisphere gastric mucosa gastrocnemius muscle inferior olivary nucleus skin of abdomen corpus callosum internal globus pallidus body of pancreas embryo Top expressed in secondary oocyte internal carotid artery external carotid artery yolk sac facial motor nucleus renal corpuscle ureter lacrimal gland cumulus cell ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity ATPase binding ubiquitin-protein transferase activity enzyme binding ATP binding transferase activity ubiquitin-ubiquitin ligase activity protein binding Cellular component ubiquitin ligase complex nucleus cytoplasm Biological process protein monoubiquitination response to endoplasmic reticulum stress ventricular trabecula myocardium morphogenesis protein ubiquitination neuron projection development granzyme-mediated apoptotic signaling pathway response to UV proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination protein polyubiquitination ubiquitin-dependent ERAD pathway ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10277 63958 Ensembl ENSG00000130939 ENSMUSG00000028960 UniProt O95155 Q9ES00 RefSeq (mRNA) NM_001105562 NM_006048 NM_022022 RefSeq (protein) NP_001099032 NP_006039 NP_071305 NP_001391797 NP_001391798 Location (UCSC) Chr 1: 10.03 – 10.18 Mb Chr 4: 149.33 – 149.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene. ^{[5] [6] [7]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000130939 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028960 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi: 10.1016/S0092-8674(00)80574-7 . PMID   10089879.
7. "Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)".

Further reading

• Onyango P, Lubyova B, Gardellin P, et al. (1998). "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics. 50 (2): 187–98. doi: 10.1006/geno.1997.5186 . PMID   9653645.
• Ohira M, Kageyama H, Mihara M, et al. (2000). "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line". Oncogene. 19 (37): 4302–7. doi:10.1038/sj.onc.1203786. PMID   10980605. S2CID   24163907.
• Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC   1222341 . PMID   11802788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kaneko C, Hatakeyama S, Matsumoto M, et al. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304. doi:10.1016/S0006-291X(02)02834-6. PMID   12504083.
• Krona C, Ejeskär K, Abel F, et al. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene. 22 (15): 2343–51. doi:10.1038/sj.onc.1206324. PMID   12700669. S2CID   7749013.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis". J. Biol. Chem. 279 (51): 53533–43. doi: 10.1074/jbc.M402916200 . PMID   15466860.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Spinette S, Mahoney JA, Rosen A (2006). "The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death". Biochem. Biophys. Res. Commun. 347 (4): 1103–12. doi:10.1016/j.bbrc.2006.06.194. PMID   16870146.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• UBE4B human gene location in the UCSC Genome Browser .
• UBE4B human gene details in the UCSC Genome Browser .