This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.[7]
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Kaneko C, Hatakeyama S, Matsumoto M, etal. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304. doi:10.1016/S0006-291X(02)02834-6. PMID12504083.
Krona C, Ejeskär K, Abel F, etal. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene. 22 (15): 2343–51. doi:10.1038/sj.onc.1206324. PMID12700669. S2CID7749013.
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