Sodium selenite

Last updated
Sodium selenite
Sodium selenite.jpg
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.030.230 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 233-267-9
KEGG
PubChem CID
RTECS number
  • VS7350000
UNII
UN number 2630
  • InChI=1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2 Yes check.svgY
    Key: BVTBRVFYZUCAKH-UHFFFAOYSA-L Yes check.svgY
  • InChI=1/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
    Key: BVTBRVFYZUCAKH-NUQVWONBAC
  • [Na+].[Na+].[O-][Se]([O-])=O
Properties
Na2O3Se
Molar mass 172.948 g·mol−1
Appearancecolourless solid
Density 3.1 g/cm3
Melting point decomposes at 710 °C
85 g/100 mL (20 °C)
Solubility insoluble in ethanol
Structure
tetragonal
Pharmacology
A12CE02 ( WHO )(Oral), B05XA20 ( WHO ) (Parenteral)
Hazards
GHS labelling:
GHS-pictogram-skull.svg GHS-pictogram-exclam.svg GHS-pictogram-pollu.svg
Danger
H300, H317, H331, H411
P261, P264, P270, P271, P272, P273, P280, P301+P310, P302+P352, P304+P340, P311, P321, P330, P333+P313, P363, P391, P403+P233, P405, P501
NFPA 704 (fire diamond)
NFPA 704.svgHealth 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
3
0
0
Safety data sheet (SDS) ICSC 0698
Related compounds
Related compounds
Sodium sulfite
Sodium selenate
Sodium selenide
sodium biselenite
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN  verify  (what is  Yes check.svgYX mark.svgN ?)

Sodium selenite is the inorganic compound with the formula Na2SeO3. This salt is a colourless solid. The pentahydrate Na2SeO3(H2O)5 is the most common water-soluble selenium compound.

Contents

Synthesis and fundamental reactions

Sodium selenite usually is prepared by the reaction of selenium dioxide with sodium hydroxide: [1]

SeO2 + 2 NaOH → Na2SeO3 + H2O

The hydrate converts to the anhydrous salt upon heating to 40 °C.

According to X-ray crystallography, both anhydrous Na2SeO3 and its pentahydrate feature pyramidal SeO32−. The Se-O distances range from 1.67 to 1.72 Å. [2] Oxidation of this anion gives sodium selenate, Na2SeO4. [3]

Applications

Together with the related barium and zinc selenites, sodium selenite is mainly used in the manufacture of colorless glass. The pink color imparted by these selenites cancels out the green color imparted by iron impurities. [4]

Because selenium is an essential element, sodium selenite is an ingredient in dietary supplements such as multi-vitamin/mineral products, but supplements that provide only selenium use L-selenomethionine or a selenium-enriched yeast.

The US Food and Drug Administration approved a selenium supplement to animal diets; the most common form is sodium selenite for pet foods. According to one article, "not much was known about which selenium compounds to approve for use in animal feeds when the decisions were made back in the 1970s .. At the time the regulatory action was taken, only the inorganic selenium salts (sodium selenite and sodium selenate) were available at a cost permitting their use in animal feed.” [5]

Sodium selenite has been proposed as an effective suicide agent. [6]

Safety

Selenium is toxic in high concentrations. As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day. [7] In 2000, the US Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 μg/day. [8] The European Food Safety Authority reviewed the same safety question and set its UL at 300 μg/day. [9]

See also

Related Research Articles

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<span class="mw-page-title-main">Selenium</span> Chemical element, symbol Se and atomic number 34

Selenium is a chemical element; it has symbol Se and atomic number 34. It is a nonmetal with properties that are intermediate between the elements above and below in the periodic table, sulfur and tellurium, and also has similarities to arsenic. It seldom occurs in its elemental state or as pure ore compounds in Earth's crust. Selenium was discovered in 1817 by Jöns Jacob Berzelius, who noted the similarity of the new element to the previously discovered tellurium.

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<span class="mw-page-title-main">Sodium selenate</span> Chemical compound

Sodium selenate is the inorganic compound with the formula Na
2
SeO
4
, not to be confused with sodium selenite. It exists as the anhydrous salt, the heptahydrate, and the decahydrate. These are white, water-soluble solids. The decahydrate is a common ingredient in multivitamins and livestock feed as a source of selenium. The anhydrous salt is used in the production of some glass. Although the selenates are much more toxic, many physical properties of sodium selenate and sodium sulfate are similar.

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References

  1. F. Féher, "Sodium Selenite" in Handbook of Preparative Inorganic Chemistry, 2nd Ed. Edited by G. Brauer, Academic Press, 1963, NY. Vol. 1. p. 432.
  2. Wickleder MS (2002). "Sodium Selenite, Na2SeO3". Acta Crystallographica Section E. 58 (11): i103–i104. Bibcode:2002AcCrE..58I.103W. doi:10.1107/S1600536802019384. ISSN   1600-5368.
  3. Mereiter K (2013). "Sodium Selenite Pentahydrate, Na2SeO3·5H2O". Acta Crystallographica Section E. 69 (11): i77–i78. doi:10.1107/S1600536813028602. PMC   3884237 . PMID   24454013.
  4. Bernd E. Langner "Selenium and Selenium Compounds" in Ullmann's Encyclopedia of Industrial Chemistry (published on-line in 2000) Wiley-VCH, Weinheim, 2002 doi : 10.1002/14356007.a23_525
  5. Schrauzer GN (2001). "Nutritional selenium supplements: product types, quality, and safety". Journal of the American College of Nutrition. 20 (1): 1–4. doi:10.1080/07315724.2001.10719007. PMID   11293463. S2CID   12668227.
  6. Nitschke, Philip (28 February 2016). The peaceful pill ehandbook. Stewart, Fiona, 1966- (January 2021 ed.). Bellingham, WA. p. 192. ISBN   978-0-9758339-1-9. OCLC   1003529499.{{cite book}}: CS1 maint: location missing publisher (link)
  7. Wilber CG (1980). "Toxicology of selenium". Clinical Toxicology. 17 (2): 171–230. doi:10.3109/15563658008985076. PMID   6998645.
  8. Institute of Medicine (2000). "Selenium". Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academies Press. pp. 284–324. doi:10.17226/9810. ISBN   978-0-309-06935-9. PMID   25077263.
  9. Tolerable Upper Intake Levels For Vitamins And Minerals (PDF), European Food Safety Authority, 2006