Births
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An incomplete list of events in Italy in 1248:
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Rubrouck is a commune in the Nord department in northern France.
Miroprofen (INN) is an analgesic and NSAID, meaning that it has anti-inflammatory, antipyretic and antiplatelet aggregation activity. Chemically it is a carbocyclic acid and a phenylpropionate.
Hugh I, Count of Blois, also known as Hugh I of Châtillon was jure uxoris Count of Blois from 1230 to 1241, and Count of Saint Pol from 1226 to 1248.
Adelaide of Merania was reigning Countess of Burgundy from 1248 until her death. She was also Countess of Savoy and Bresse through her marriage in 1267 to Count Philip I of Savoy.
Just before each crus of the penis meets its fellow, it presents a slight enlargement, which Georg Ludwig Kobelt named the bulb of the corpus cavernosum penis. The bulb of penis is also known as the urethral bulb.
Simon Langton was an English medieval clergyman who served as Archdeacon of Canterbury from 1227 until his death in 1248. He had previously been Archbishop-elect of York, but the election was quashed by Pope Innocent III.
Flutazolam is a drug which is a benzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and though it is around the same potency as diazepam, it produces a more marked sedation and impaired coordination. It is indicated for the treatment of insomnia. Its major active metabolite is n-desalkylflurazepam, also known as norflurazepam, which is also a principal metabolite of flurazepam. While flutazolam has a very short half-life of only 3.5 hours, n-desalkylflurazepam has a long half-life of between 47–100 hours.
Events from the year 1248 in Ireland.
Yolande of Dreux (1212–1248) was Duchess of Burgundy as the first wife of Hugh IV of Burgundy.
Domiati cheese, also referred to as white cheese, is a soft white salty cheese made primarily in Egypt, but also in Sudan and other Middle Eastern countries. Typically made from buffalo milk, cow milk, or a mixture, it can also be made from other milks, such as sheep, goat or camel milk. It is the most common Egyptian cheese. Unlike feta and other white cheeses, salt is added directly to the milk, before rennet is added. It is named after the seaport city of Damietta (دمياط).
Kidal is a Hindu temple built under the Singhasari dynasty. It is situated in the Rejokidal village in the Tumpang district of East Java, approximately 20 km east of Malang. The temple was built around 1248 and restored in the 1990s. The temple is composed of three levels that are situated on a raised platform. At the foot of the temple, three Javanese masks depict the story of Garuda. The temple may have encased an image of Shiva depicted by the portrait of the Singhasari king, Anusapati.
Amfenac, also known as 2-amino-3-benzoylbenzeneacetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with acetic acid moiety.
α-Viniferin is a stilbene trimer. It can be isolated from Caragana chamlagu and from Caragana sinica and from the stem bark of Dryobalanops aromatica. It is also present in relation to resistance to Botrytis cinerea and Plasmopara viticola in Vitis vinifera and Vitis riparia.It has been shown to inhibit acetylcholinesterase.
An annular solar eclipse will occur on November 27, 2095. A solar eclipse occurs when the Moon passes between Earth and the Sun, thereby totally or partly obscuring the image of the Sun for a viewer on Earth. An annular solar eclipse occurs when the Moon's apparent diameter is smaller than the Sun's, blocking most of the Sun's light and causing the Sun to look like an annulus (ring). An annular eclipse appears as a partial eclipse over a region of the Earth thousands of kilometres wide.
Xibenolol is a beta blocker.
AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with an adamantoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position. The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another synthetic cannabinoid AM-679.
Cannabipiperidiethanone is a synthetic cannabinoid that has been found as an ingredient of "herbal" synthetic cannabis blends sold in Japan, alongside JWH-122 and JWH-081.
YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM). It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2, which is required for full transactivation of the AR. The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard. It has been investigated as a potential treatment for sepsis-induced muscle wasting in animal studies.
Fluoromedroxyprogesterone acetate is a synthetic steroid medication which was under development by Meiji Dairies Corporation in the 1990s and 2000s for the potential treatment of cancers but was never marketed. It is described as an antiangiogenic agent, with about two orders of magnitude greater potency for inhibition of angiogenesis than its parent compound medroxyprogesterone acetate. FMPA showed about the same affinities for the progesterone and glucocorticoid receptors as MPA. It reached the preclinical phase of research prior to the discontinuation of its development.