The following are the baseball events of the year 1880 throughout the world.
Inter-league playoff: Washington (NA) defeat Chicago (NL), 4 games to 3 (1 tie game)
| National League | ||
|---|---|---|
| Stat | Player | Total |
| AVG | George Gore (CHI) | .360 |
| HR | Jim O'Rourke (BOS) Harry Stovey (WOR) | 6 |
| RBI | Cap Anson (CHI) | 74 |
| W | Jim McCormick (CLE) | 45 |
| ERA | Tim Keefe (TRO) | 0.86 |
| K | Larry Corcoran (CHI) | 268 |
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