The following are the baseball events of the year 1881 throughout the world.
Inter-league playoff: New York Mets (ECA) defeat Chicago (NL), 2 games to 1.
| National League | ||
|---|---|---|
| Stat | Player | Total |
| AVG | Cap Anson (CHI) | .399 |
| HR | Dan Brouthers (BUF) | 8 |
| RBI | Cap Anson (CHI) | 82 |
| W | Larry Corcoran (CHI) Jim Whitney (BSN) | 31 |
| ERA | Stump Weidman (DET) | 1.80 |
| K | George Derby (DET) | 212 |
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