2-aminoadipate transaminase

2-aminoadipate transaminase
Identifiers
EC no.	2.6.1.39
CAS no.	9033-00-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, 2-aminoadipate transaminase (EC 2.6.1.39) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipic acid

+

 

α-Ketoglutaric acid

 

 

 

 

 

 

2-Oxoadipic acid

+

 

L-Glutamic acid

The two substrates of this enzyme are L-2-aminoadipic acid and α-Ketoglutaric acid. Its products are 2-oxoadipic acid and L-glutamic acid. ^{[1] [2]}

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-2-aminoadipate:2-oxoglutarate aminotransferase. Other names in common use include alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, glutamic-ketoadipic transaminase, and glutamate-alpha-ketoadipate transaminase. This enzyme participates in lysine biosynthesis and lysine degradation. It employs one cofactor, pyridoxal phosphate. ^[3]

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DTV.

References

1. Enzyme 2.6.1.39 at KEGG Pathway Database.
2. Matsuda M, Ogur M (1969). "Separation and specificity of the yeast glutamate-alpha-ketoadipate transaminase". J. Biol. Chem. 244 (12): 3352–8. doi: 10.1016/S0021-9258(18)93133-9 . PMID   5792664.
3. Voet, Donald; Voet, Judith G. (2011). Biochemistry (4th ed.). Hoboken, NJ: Wiley. pp. 1040–41. ISBN   978-0-470-91745-9.