National team
Men's national team
| 31 March 2010 International Friendly | Paraguay  | 1 – 1 |  South Africa | Asunción, Paraguay |
| 18:00 UTC-3 | Estigarribia  37' | Report | Tshabalala 71' | Stadium: Estadio Defensores del Chaco Attendance: 15,000 |
| 15 May 2010 International Friendly | Paraguay | 1 – 0 |  North Korea | Nyon, Switzerland |
| 18:00 UTC-2 | Santa Cruz 86' (pen.) | Report | Stadium: Centre sportif de Colovray Nyon |
| 25 May 2010 International Friendly | Republic of Ireland  | 2 – 1 | Paraguay | Dublin, Ireland |
| 19:45 UTC+1 | Kevin Doyle 7' Liam Lawrence 39' | Report | Lucas Barrios 58' | Stadium: RDS Arena Attendance: 16,722 |
| 30 May 2010 International Friendly | Paraguay | 2 – 2 |  Ivory Coast | Thonon-les-Bains, France |
| 18:00 UTC+2 | Barrios 74' Torres 90' | Report | Drogba 52' Bamba 73' | Stadium: Stade Joseph-Moynat |
| 2 June 2010 International Friendly | Greece  | 0 – 2 | Paraguay | Winterthur, Switzerland |
| 18:30 UTC+2 | Report | Vera 9' Barrios 24' | Stadium: Stadion Schützenwiese |
| 14 June 2010 2010 FIFA World Cup | Italy  | 1 – 1 | Paraguay | Cape Town, South Africa |
| 18:00 UTC+2 | De Rossi 63' | Report | Alcaraz 39' | Stadium: Cape Town Stadium Attendance: 62,869 Referee: Benito Archundia (Mexico) |
| 20 June 2010 2010 FIFA World Cup | Slovakia  | 0 – 2 | Paraguay | Bloemfontein, South Africa |
| 13:30 UTC+2 | Report | Vera 27' Riveros 86' | Stadium: Free State Stadium Attendance: 26,643 Referee: Eddy Maillet (Seychelles) |
| 24 June 2010 2010 FIFA World Cup | Paraguay | 0 – 0 |  New Zealand | Polokwane, South Africa |
| 16:00 UTC+2 | Report | Stadium: Peter Mokaba Stadium Attendance: 34,850 Referee: Yuichi Nishimura (Japan) |
| 29 June 2010 2010 FIFA World Cup | Paraguay | 0 – 0 (a.e.t.) (5 – 3 p) |  Japan | Pretoria, South Africa |
| 16:00 UTC+2 | Report | Stadium: Loftus Versfeld Stadium Attendance: 36,742 Referee: Frank De Bleeckere (Belgium) | ||
| Penalties | ||||
Barreto  Barrios Riveros Valdez Cardozo | Endō Hasebe  Komano Honda | |||
| 3 July 2010 2010 FIFA World Cup | Paraguay | 0 – 1 |  Spain | Johannesburg, South Africa |
| 20:30 UTC+2 | Report | Villa 83' | Stadium: Ellis Park Stadium Attendance: 55,359 Referee: Carlos Batres (Guatemala) |
| 11 August 2010 International Friendly | Paraguay | 2 – 0 |  Costa Rica | Asunción, Paraguay |
| 20:00 UTC-4 | Vera 7' Riveros 73' | Stadium: Estadio Defensores del Chaco Attendance: 25,000 |
| 4 September 2010 International Friendly | Japan | 1 – 0 | Paraguay | Yokohama, Japan |
| 19:20 UTC+9 | Kagawa 64' | Stadium: International Stadium Yokohama Attendance: 65,157 |
| 7 September 2010 International Friendly | China  | 1 – 1 | Paraguay | Nanjing, China |
| 19:35 UTC+8 | Gao Lin 33' | Barrios 8' | Stadium: Nanjing Olympic Sports Center |
| 9 October 2010 International Friendly | Australia  | 1 – 0 | Paraguay | Sydney, Australia |
| 20:00 UTC+10 | Carney 53' | Stadium: Sydney Football Stadium |
| 12 October 2010 International Friendly | New Zealand | 0 – 2 | Paraguay | Wellington, New Zealand |
| 19:30 UTC+13 | Valdez 22' (pen.) Martínez 27' | Stadium: Westpac Stadium Attendance: 16,477 Referee: Jamie Cross |
| 17 November 2010 International Friendly | Hong Kong  | 0 – 7 | Paraguay | Hong Kong |
| 20:00 UTC+8 | Santa Cruz 4', 32' Barreto 30'Ortigoza 47', 55'M.Riveros 75'C.Riveros 90' | Stadium: Hong Kong Stadium Attendance: 6,250 |
Women's national team
| November 5, 2010 2010 Sudamericano Femenino | Paraguay | 0–3 |  Colombia | Loja, Ecuador |
| 17:00 UTC-5 | Report [ permanent dead link ] | Domínguez 18' Uzme 46'Rincón 70' | Stadium: Estadio Federativo Reina del Cisne |
| November 7, 2010 2010 Sudamericano Femenino | Venezuela  | 0–4 | Paraguay | Loja, Ecuador |
| 11:00 UTC-5 | Report | Quintana 49' Villamayor 56', 59', 80' | Stadium: Estadio Federativo Reina del Cisne |
| November 9, 2010 2010 Sudamericano Femenino | Paraguay | 4–0 |  Uruguay | Azogues, Ecuador |
| 16:00 UTC-5 | Villamayor 29' Galeano 38'Quintana 42'Vásquez 89' (pen.) | Report [ permanent dead link ] | Stadium: Estadio Jorge Andrade |
| November 13, 2010 2010 Sudamericano Femenino | Brazil  | 3–0 | Paraguay | Cuenca, Ecuador |
| 16:00 UTC-5 | Cristiane 18', 36' Marta 57' | Report [ permanent dead link ] | Stadium: Estadio Alejandro Serrano Aguilar |
