| 2019 Las Vegas Challenger | |
|---|---|
| Date | 14 – 20 October |
| Edition | 5th |
| Draw | 48S / 16D |
| Surface | Hard / Outdoors |
| Location | Las Vegas, United States |
| Champions | |
| Singles | |
 Vasek Pospisil | |
| Doubles | |
 Ruben Gonzales /  Ruan Roelofse | |
The 2019 Las Vegas Challenger was a professional tennis tournament played on hard courts. It was the fifth edition of the revamped tournament which was the part of the 2019 ATP Challenger Tour. It took place in Las Vegas, United States between 14 and 20 October 2019.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 USA | Steve Johnson | 99 | 1 |
 JPN | Taro Daniel | 111 | 2 |
| USA | Marcos Giron | 126 | 3 |
 SLO | Blaž Rola | 131 | 4 |
 AUS | James Duckworth | 143 | 5 |
 ECU | Emilio Gómez | 147 | 6 |
| CAN | Peter Polansky | 163 | 7 |
 BAR | Darian King | 171 | 8 |
 ESP | Nicola Kuhn | 174 | 9 |
| AUS | Christopher O'Connell | 192 | 10 |
| USA | Mitchell Krueger | 201 | 11 |
 KAZ | Dmitry Popko | 209 | 12 |
| USA | Jack Sock | 210 | 13 |
 CHI | Alejandro Tabilo | 224 | 14 |
| USA | Donald Young | 233 | 15 |
| USA | Jeffrey John Wolf | 241 | 16 |
The following players received wildcards into the singles main draw:
Alexander Cozbinov Steve Johnson Alex Kobelt Stefan Kozlov Evan SongThe following players received entry from the qualifying draw:
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