| 2019 Amex-Istanbul Challenger | |
|---|---|
| Date | 9–15 September |
| Edition | 32nd |
| Surface | Hard |
| Location | Istanbul, Turkey |
| Champions | |
| Singles | |
 Ugo Humbert | |
| Doubles | |
 Andrey Golubev / Aleksandr Nedovyesov | |
The 2019 Amex-Istanbul Challenger was a professional tennis tournament played on hard courts. It was the 32nd edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Istanbul, Turkey between 9 and 15 September 2019.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| FRA | Ugo Humbert | 63 | 1 |
 ESP | |||
 ROU | Marius Copil | 93 | 3 |
 TUN | |||
 UZB | Denis Istomin | 139 | 5 |
 CZE | Lukáš Rosol | 152 | 6 |
| FRA | Maxime Janvier | 176 | 7 |
 IND | Ramkumar Ramanathan | 177 | 8 |
 ITA | Roberto Marcora | 180 | 9 |
 BEL | Ruben Bemelmans | 181 | 10 |
 GBR | Jay Clarke | 187 | 11 |
| ESP | Nicola Kuhn | 191 | 12 |
| KAZ | Aleksandr Nedovyesov | 226 | 13 |
 RUS | Roman Safiullin | 230 | 14 |
 COL | |||
 SLO | Blaž Kavčič | 239 | 16 |
| ITA | Matteo Viola | 240 | 17 |
The following players received wildcards into the singles main draw:
Baran Cengiz Marsel İlhan 
Holger Rune Kirill Saplin Mert Naci Türker The following players received entry into the singles main draw as alternates:
Sander Arends Victor Vlad Cornea Mikhail Elgin Marek Gengel Burak Can Yılmaz Ugo Humbert def. Denis Istomin 6–2, 6–2. Andrey Golubev / Aleksandr Nedovyesov def. Marek Gengel / Lukáš Rosol Walkover.