| 2018 Amex-Istanbul Challenger | |
|---|---|
| Date | 10–16 September |
| Edition | 31st |
| Surface | Hard |
| Location | Istanbul, Turkey |
| Champions | |
| Singles | |
 Corentin Moutet | |
| Doubles | |
 Rameez Junaid /  Purav Raja | |
The 2018 Amex-Istanbul Challenger was a professional tennis tournament played on hard courts. It was the 31st edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Istanbul, Turkey between 10 and 16 September 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ITA | Thomas Fabbiano | 110 | 1 |
| FRA | Corentin Moutet | 112 | 2 |
 ESP | Adrián Menéndez Maceiras | 114 | 3 |
| FRA | Quentin Halys | 156 | 4 |
| FRA | Constant Lestienne | 171 | 5 |
 GER | Oscar Otte | 183 | 6 |
 NED | Tallon Griekspoor | 187 | 7 |
 AUT | Lucas Miedler | 219 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Corentin Moutet def. Quentin Halys 6–3, 6–4. Rameez Junaid / Purav Raja def. 
Timur Khabibulin / 
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