| 2018 Jalisco Open | |
|---|---|
| Date | 16–22 April |
| Edition | 8th |
| Draw | 32S / 16D |
| Surface | Hard |
| Location | Guadalajara, Mexico |
| Champions | |
| Singles | |
 Marcelo Arévalo | |
| Doubles | |
Marcelo Arévalo /  Miguel Ángel Reyes-Varela | |
The 2018 Jalisco Open was a professional tennis tournament played on hard courts. It was the eighth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Guadalajara, Mexico between 16 and 22 April 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Adrián Menéndez Maceiras | 141 | 1 |
 GER | Mats Moraing | 156 | 2 |
 USA | Dennis Novikov | 167 | 3 |
 CAN | Filip Peliwo | 169 | 4 |
| USA | Kevin King | 171 | 5 |
| ESA | Marcelo Arévalo | 174 | 6 |
 DOM | Víctor Estrella Burgos | 177 | 7 |
 BAR | Darian King | 183 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Marcelo Arévalo def. Christopher Eubanks 6–4, 5–7, 7–6(7–4). Marcelo Arévalo / Miguel Ángel Reyes-Varela def. 
Brydan Klein / 
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