| 2018 Uruguay Open | |
|---|---|
| Date | 5–11 November |
| Edition | 14th |
| Surface | Clay |
| Location | Montevideo, Uruguay |
| Champions | |
| Singles | |
 Guido Pella | |
| Doubles | |
| Guido Andreozzi / Guillermo Durán | |
The 2018 Uruguay Open was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between November 5 and 11, 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 URU | Pablo Cuevas | 65 | 1 |
| ARG | Guido Pella | 66 | 2 |
| ARG | Guido Andreozzi | 97 | 3 |
 ESP | Pablo Andújar | 103 | 4 |
 BRA | Thiago Monteiro | 114 | 5 |
 BOL | Hugo Dellien | 115 | 6 |
 ITA | Paolo Lorenzi | 116 | 7 |
| ARG | Juan Ignacio Londero | 119 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Federico Coria Facundo Díaz Acosta Juan Ignacio Galarza
Dimitar Kuzmanov Guido Pella def. Carlos Berlocq 6–3, 3–6, 6–1. Guido Andreozzi / Guillermo Durán def. Facundo Bagnis / Andrés Molteni 7–6(7–5), 6–4.