| 2018 Karshi Challenger | |
|---|---|
| Date | 7–12 May |
| Edition | 12th |
| Draw | 32S / 16D |
| Surface | Hard |
| Location | Qarshi, Uzbekistan |
| Champions | |
| Singles | |
 Egor Gerasimov | |
| Doubles | |
 Timur Khabibulin /  Vladyslav Manafov | |
The 2018 Karshi Challenger was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Qarshi, Uzbekistan between 7 and 12 May 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 POL | Hubert Hurkacz | 178 | 1 |
 SRB | Nikola Milojević | 208 | 2 |
| BLR | Egor Gerasimov | 224 | 3 |
| BLR | Uladzimir Ignatik | 226 | 4 |
| KAZ | Aleksandr Nedovyesov | 228 | 5 |
 RSA | Lloyd Harris | 232 | 6 |
 BIH | Aldin Šetkić | 245 | 7 |
 TPE | Yang Tsung-hua | 249 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Sergey Betov 
Tristan Lamasine 
Sasikumar Mukund 
Shuichi Sekiguchi Egor Gerasimov def. Sergey Betov 7–6(7–3), 2–0 ret. Timur Khabibulin / Vladyslav Manafov def. 
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