| 2018 Puerto Vallarta Open | |
|---|---|
| Date | 30 April – 5 May |
| Edition | 1st |
| Draw | 32S / 16D |
| Surface | Hard |
| Location | Puerto Vallarta, Mexico |
| Champions | |
| Singles | |
 Adrián Menéndez Maceiras | |
| Doubles | |
 Ante Pavić /  Danilo Petrović | |
The 2018 Puerto Vallarta Open was a professional tennis tournament played on hard courts. It was the 1st edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Puerto Vallarta, Mexico between 30 April and 5 May.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ESP | Adrián Menéndez Maceiras | 151 | 1 |
 DOM | Víctor Estrella Burgos | 168 | 2 |
 USA | Kevin King | 173 | 3 |
| USA | Christopher Eubanks | 246 | 4 |
| SRB | Danilo Petrović | 247 | 5 |
| USA | Alexander Sarkissian | 257 | 6 |
| DOM | José Hernández-Fernández | 261 | 7 |
 ECU | Roberto Quiroz | 280 | 8 |
The following players received wildcards into the singles main draw:
Tigre Hank Gerardo López Villaseñor Manuel Sánchez Marcelo SepúlvedaThe following players received entry into the singles main draw using protected rankings:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Viktor Durasovic 
Felipe Mantilla
Luis David Martínez Evan Song Adrián Menéndez Maceiras def. Danilo Petrović 1–6, 7–5, 6–3. Ante Pavić / Danilo Petrović def. 
Benjamin Lock / 
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