| XVI Venice Challenge Save Cup | |
|---|---|
| Date | 21–27 May |
| Edition | 5th |
| Draw | 32S / 16D |
| Surface | Clay |
| Location | Mestre, Italy |
| Champions | |
| Singles | |
 Gianluigi Quinzi | |
| Doubles | |
 Marin Draganja / Tomislav Draganja | |
The XVI Venice Challenge Save Cup was a professional tennis tournament played on clay courts. It was the 5th edition of the men's tournament which was part of the 2018 ATP Challenger Tour. It took place in Mestre, Italy between 21 and 27 May 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 BEL | Arthur De Greef | 222 | 1 |
 SRB | Danilo Petrović | 232 | 2 |
 TPE | Yang Tsung-hua | 240 | 3 |
| ITA | Gianluigi Quinzi | 247 | 4 |
 BIH | Tomislav Brkić | 250 | 5 |
 USA | Mitchell Krueger | 252 | 6 |
| ITA | Lorenzo Giustino | 255 | 7 |
 ESP | Carlos Boluda-Purkiss | 256 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
Edoardo Eremin Federico Gaio Roberto Marcora 
Daniel Masur Gianluigi Quinzi def. Gian Marco Moroni 6–2, 6–2. Marin Draganja / Tomislav Draganja def. 
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