| 2018 Knoxville Challenger | |
|---|---|
| Date | 5–11 November |
| Edition | 15th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Reilly Opelka | |
| Doubles | |
 Toshihide Matsui /  Frederik Nielsen | |
The 2018 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the fifteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Knoxville, United States between 5 and 11 November 2018.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Tennys Sandgren | 62 | 1 |
 ESP | Marcel Granollers | 98 | 2 |
| USA | Bradley Klahn | 101 | 3 |
| USA | Michael Mmoh | 102 | 4 |
| USA | Tim Smyczek | 120 | 5 |
 TPE | Jason Jung | 126 | 6 |
 CAN | Peter Polansky | 130 | 7 |
| USA | Reilly Opelka | 134 | 8 |
The following players received wildcards into the singles main draw:
Tennys Sandgren 
Timo Stodder Preston Touliatos Jeffrey John Wolf The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Emilio Gómez Michael Redlicki Evan Song
Mikael Ymer Reilly Opelka def. Bjorn Fratangelo 7–5, 4–6, 7–6(7–2). Toshihide Matsui / Frederik Nielsen def. Hunter Reese / Tennys Sandgren 7–6(8–6), 7–5.The 2011 Levene Gouldin & Thompson Tennis Challenger was a professional tennis tournament played on hard courts. It was the 18th edition of the tournament which was part of the 2011 ATP Challenger Tour. It took place in Binghamton, United States between 8 and 14 August 2011.
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