| 2019 Cary Challenger | |
|---|---|
| Date | 9–15 September |
| Edition | 5th |
| Draw | 48S / 16D |
| Surface | Hard |
| Location | Cary, North Carolina, United States |
| Champions | |
| Singles | |
 Andreas Seppi | |
| Doubles | |
 Sekou Bangoura / Michael Mmoh | |
The 2019 Cary Challenger was a professional tennis tournament played on hard courts. It was the 5th edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Cary, North Carolina, United States between 9 and 15 September 2019.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ITA | Andreas Seppi | 77 | 1 |
| USA | Tommy Paul | 114 | 2 |
| USA | Bjorn Fratangelo | 117 | 3 |
| USA | Marcos Giron | 151 | 4 |
 FRA | Enzo Couacaud | 169 | 5 |
 DEN | Mikael Torpegaard | 173 | 6 |
| USA | Mitchell Krueger | 174 | 7 |
| USA | Christopher Eubanks | 188 | 8 |
 CAN | Peter Polansky | 192 | 9 |
| USA | Noah Rubin | 195 | 10 |
| USA | Michael Mmoh | 196 | 11 |
| USA | Donald Young | 197 | 12 |
| USA | Thai-Son Kwiatkowski | 204 | 13 |
 COL | Daniel Elahi Galán | 207 | 14 |
 JPN | |||
 AUS | John-Patrick Smith | 241 | 16 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
Liam Caruana Christian Langmo Dennis Novikov The following players received entry from the qualifying draw:
Petros Chrysochos Connor Farren Andreas Seppi def. Michael Mmoh 6–2, 6–7(4–7), 6–3. Sekou Bangoura / Michael Mmoh def. 
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