Madison Keys was the defending champion, but withdrew with a wrist injury before the tournament began.
Simona Halep was the defending champion, but lost in the semifinals to Elina Svitolina.
Karolína Plíšková was the defending champion, but lost in the semifinals to Garbiñe Muguruza.
Petra Kvitová was the defending champion, but lost in the first round to Peng Shuai.
Agnieszka Radwańska was the defending champion, but lost in the third round to Daria Kasatkina.
Angelique Kerber defeated Serena Williams in the final, 6–3, 6–3 to win the ladies' singles tennis title at the 2018 Wimbledon Championships. It was her third major singles title, and she became the first German since Steffi Graf in 1996 to win the title. She lost only one set during the tournament, to Claire Liu in the second round. Williams was attempting to equal Margaret Court's all-time record of 24 major singles titles, and to become the first mother to win a major singles title since Kim Clijsters won the 2011 Australian Open.
Naomi Osaka defeated Serena Williams in the final, 6–2, 6–4 to win the women's singles tennis title at the 2018 US Open. She became the first Japanese to win a major singles title. She lost only one set during the tournament, to Aryna Sabalenka in the fourth round. Following the win, Osaka also made her top 10 rankings debut.
Elina Svitolina was the defending champion, but lost to Sloane Stephens in the semifinals.
Garbiñe Muguruza was the defending champion, but lost in the second round to Lesia Tsurenko.
Naomi Osaka defeated Petra Kvitová 7–6(7–2), 5–7, 6–4 in the final to win the women's singles tennis title at the 2019 Australian Open. By winning the tournament, Osaka took over the WTA no. 1 singles ranking from Simona Halep and also became the first player since Jennifer Capriati to win their first two Grand Slam titles in consecutive fashion. Eleven players had a theoretical chance of becoming no. 1 at the start of the tournament. In addition to Kvitová and Osaka, Sloane Stephens, Karolína Plíšková, Angelique Kerber, Elina Svitolina, Kiki Bertens, Aryna Sabalenka and Daria Kasatkina were also in contention for the no. 1 ranking at the start of this tournament, but were eliminated from contention as the tournament progressed.
Ashleigh Barty defeated Karolína Plíšková in the final, 7–6(7–1), 6–3, to win the women's singles tennis title at the 2019 Miami Open. It marked Barty's first Miami Open title and her first WTA Premier Mandatory title. Her victory earned her a top 10 debut in the WTA rankings.
Ashleigh Barty defeated Markéta Vondroušová in the final, 6–1, 6–3 to win the women's singles tennis title at the 2019 French Open. It was her first major singles title, making her the first Australian to win a French Open singles title since Margaret Court in 1973 and the first to win a major singles title since Samantha Stosur at the 2011 US Open. Vondroušová was the first teenager to reach the final since Ana Ivanovic in 2007, as well as the first teenager to reach a major women's singles final since Caroline Wozniacki at the 2009 US Open.
Bianca Andreescu defeated Serena Williams in the final, 6–3, 7–5 to win the women's singles tennis title at the 2019 US Open. It was her first major title, and she became the first Canadian, as well as the first player born in the 2000s, to win a major singles title. In addition, she was the youngest person since Svetlana Kuznetsova in 2004 to win a major singles title and the first woman to win the US Open on her main draw debut. With the win, Andreescu entered the top 5 in rankings for the first time.
Sofia Kenin won her first Grand Slam title, defeating Garbiñe Muguruza in the final, 4–6, 6–2, 6–2. Kenin became the first American woman, other than Serena Williams, to win the Australian Open women's singles title since Jennifer Capriati in 2002. Kenin was the youngest Australian Open finalist since Ana Ivanovic and the youngest champion since Maria Sharapova, both in 2008. Muguruza was the first unseeded player, without being awarded a wildcard or entering through a protected ranking, to reach the Australian Open final since Serena Williams in 2007. This was the first Australian Open final in the Open Era to be contested between two players ranked outside the top ten, and the first Grand Slam final to feature two players outside the top ten since the 2018 US Open final. Kenin entered the world's top 10 rankings for the first time in her career by winning the title.
Elise Mertens was the defending champion, but lost in the second round to Yulia Putintseva.
Ashleigh Barty was the defending champion from when the tournament was last held in 2019, and she successfully defended her title after Bianca Andreescu retired from the final with the scoreline at 6–3, 4–0. Barty saved a match point in the second round against Kristína Kučová en route to the title. The victory earned Barty her first successful title defense in her singles career and made her the sixth woman to accomplish a title defense at the Miami Open.
Aryna Sabalenka defeated Ashleigh Barty in the final, 6–0, 3–6, 6–4, to win the women's singles tennis title at the 2021 Madrid Open. It was Sabalenka's 10th career WTA Tour singles title and her first title on clay.
Ashleigh Barty defeated Jil Teichmann in the final, 6–3, 6–1, to win the women's singles title at the 2021 Cincinnati Masters and her first title at the tournament. Barty won the title without dropping a set. It was her fifth and last title of the season, her third WTA 1000 title, and her 13th career singles title overall on the WTA Tour.
Paula Badosa defeated Barbora Krejčíková in the final, 6–3, 4–6, 7–6(7–4) to win the women's singles tennis title at the 2022 Sydney Tennis Classic. Krejčíková reached the final after having saved seven match points in her semifinal match against Anett Kontaveit.
Iga Świątek defeated Naomi Osaka in the final, 6–4, 6–0 to win the women's singles title at the 2022 Miami Open. She became the fourth woman in history, after Steffi Graf, Kim Clijsters, and Victoria Azarenka, to complete the Sunshine Double in singles, having won Indian Wells two weeks earlier. It was Świątek's first Miami Open title, her third consecutive WTA 1000 title, and her fourth WTA 1000-level title overall. Świątek became the first woman in history to win the first three WTA 1000 titles of the year in succession, the first player since Serena Williams in 2013 to win three consecutive WTA 1000 titles, and extended her win streak to 17 matches. She lost no sets and just 26 games en route to the title, the fewest since Martina Hingis dropped 21 games in 2000.
Ashleigh Barty 
Garbiñe Muguruza 
