4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

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4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
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EC no. 3.7.1.17
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4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17, tesD (gene), hsaD (gene)) is an enzyme with systematic name 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming). [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate

The enzyme is involved in the bacterial degradation of the steroid ring structure.

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TESD may refer to:

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Biphenyl-2,3-diol 1,2-dioxygenase (EC 1.13.11.39) is an enzyme that catalyzes the chemical reaction

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  1. (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + succinate
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HSAD may refer to:

2-hydroxyhexa-2,4-dienoate hydratase (EC 4.2.1.132, tesE (gene), hsaE (gene)) is an enzyme with systematic name 4-hydroxy-2-oxohexanoate hydro-lyase ((2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming). This enzyme catalyses the following chemical reaction

References

  1. ↑ Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T (September 2005). "Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441". Applied and Environmental Microbiology. 71 (9): 5275–81. Bibcode:2005ApEnM..71.5275H. doi:10.1128/aem.71.9.5275-5281.2005. PMC   1214608 . PMID   16151114.
  2. ↑ Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD (February 2007). "A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages". Proceedings of the National Academy of Sciences of the United States of America. 104 (6): 1947–52. Bibcode:2007PNAS..104.1947V. doi: 10.1073/pnas.0605728104 . PMC   1794314 . PMID   17264217.
  3. ↑ Lack N, Lowe ED, Liu J, Eltis LD, Noble ME, Sim E, Westwood IM (January 2008). "Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis". Acta Crystallographica Section F. 64 (Pt 1): 2–7. doi:10.1107/s1744309107065931. PMC   2373992 . PMID   18097091.
  4. ↑ Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD (January 2010). "Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism". The Journal of Biological Chemistry. 285 (1): 434–43. doi: 10.1074/jbc.m109.058081 . PMC   2804191 . PMID   19875455.
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